三阴性乳腺癌与非三阴性乳腺癌COMT、APOE基因多态性的差异性研究

目的 探讨三阴性乳腺癌(TNBC)与非三阴性乳腺癌(NTNBC)患者COMT、APOE基因多态性的差异,从而解释化疗后认知障碍发生.方法 对60例TNBC和60例NTN-BC化疗后的患者进行COMT(rs165599、rs4680、rs737865),APOE(rs429358、rs7412)5个单核苷酸多态性(SNP)位点的等位基因频率、基因型频率检测.结果 单位点分析结果表明,与NTNBC相比,TNBC在COMT(rs737865)位点上的等位基因分布(P=0.013),基因型分布(P=0.010)方面差异有统计学意义,而在APOE(rs429358,rs7412)方面两组差异无统计学意义.结论 提示TNBC患者COMT基因的多态性可能是其化疗后认知障碍发生的易感性因子.

Differential research on COMT,APOE polymorphisms in triple-negative breast cancer and non-triple negative breast cancer patients

Objective To investigate the differences of the COMT ( catechol-O-methyltransferase) and APOE( apo-lipoprotein E) gene polymorphisms in triple-negative breast cancer ( TNBC) and non-triple negative breast cancer ( NTNBC) patients, so as to explain the occurrence chemotherapy-induced cognitive impairment in breast cancer patients. Methods 60 TNBC and 60 NTNBC patients after chemotherapy respectively underwent five SNP loci al-lele frequency and genotype frequency detection on COMT ( rs165599 , rs4680 , rs737865 ) , APOE ( rs429358 , rs7412). Results Compared with NTNBC survivors, there was a significant difference in TNBC on the COMT (rs737865) loci allele (P=0. 013) and genotype (P=0. 010), and in respect of APOE (rs429358,rs7412) was no statistically significant differences between the two groups. Conclusion It indicates that the COMT gene poly-morphisms could be a susceptibility factor for cognitive dysfunction in TNBC survivors.