|
|||||
|
|
| Determination of ribavirin by flow injection chemiluminescence | |
| 引用本文： | Juqing Jin,Yuhai Tang,Langchong He,Hong Yao,Yuanyuan Sun. Determination of ribavirin by flow injection chemiluminescence[J]. 南京医科大学学报(自然科学版), 2006, 20(5): 266-270 |
| 作者姓名： | Juqing Jin Yuhai Tang Langchong He Hong Yao Yuanyuan Sun |
| 作者单位： | [1]School of Science . Xi＇an Jiaotong University, Xi＇an 710061 ,China [2]School of Medicine, Xi＇an Jiaotong University, Xi＇an 710061 ,China [3]Pharmacy Faculty of Fujian Medical University ,Fuzhou 350004 ,China |
| 摘 要： | Objective： To establish a rapid and precise continuous flow-injection chemiluminescence （CL） method to determine ribavirin. Methods： The ribavirin could restrain strongly CL reaction of luminol in sodium hydroxide （NaOH） solution with potassium chlorate （KClO3）. The different experimental parameters affecting the CL intensity were studied carefully. Results： Under optimum conditions （The concentrations of luminol, KClO3, and NaOH were at 0.1 mmol/L, 0.5μmol/L, and 0.2 mol/L, respectively）, the linear range of the working curves was 0.01-7.00μg/ml with a detection limit of 0.004μg/ml. Conclusion： The method is simple, rapid and sensitive, and successfully applied to the determination of ribavirin in pharmaceutical preparations and biological fluids. |
| 关 键 词： | 病毒唑 化学发光 氯酸盐 药物 |
| 收稿时间： | 2006-03-16 |
Determination of ribavirin by flow injection chemiluminescence |
|
| Juqing Jin,Yuhai Tang,Langchong He,Hong Yao,Yuanyuan Sun. Determination of ribavirin by flow injection chemiluminescence[J]. Acta Universitatis Medicinalis Nanjing, 2006, 20(5): 266-270 | |
| Authors: | Juqing Jin Yuhai Tang Langchong He Hong Yao Yuanyuan Sun |
| Abstract: | Objective: To establish a rapid and precise continuous flow-injection chemiluminescence(CL) method to determine ribavirin. Methods: The ribavirin could restrain strongly CL reaction of luminol in sodium hydroxide (NaOH) solution with potassium chlorate(KClO3). The different experimental parameters affecting the CL intensity were studied carefully. Results: Under optimum conditions(The concentrations of luminol,KClO3, and NaOH were at 0.1 mmol/L,0.5 ?mol/L,and 0.2 mol/L, respectively), the linear range of the working curves was 0.01-7.00 g/ml with a detection limit of 0.004 g/ml. Conclusion: The method is simple, rapid and sensitive, and successfully applied to the determination of ribavirin in pharmaceutical preparations and biological fluids. |
| Keywords: | flow injection analysis chemiluminescence ribavirin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《南京医科大学学报(自然科学版)》浏览原始摘要信息 | |
| 点击此处可从《南京医科大学学报(自然科学版)》下载全文 | |