Genetic diversity of HLA system in two populations from Oaxaca,Mexico: Oaxaca city and rural Oaxaca |
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| Affiliation: | 1. Immunogenetics Unit, Técnicas Genéticas Aplicadas a la Clínica (TGAC), Mexico City, Mexico;2. Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico;3. Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany;4. Histocompatibility Laboratory, Unidad Médica de Alta Especialidad (UMAE) # 6, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, Mexico;5. Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany;6. Blood Bank, UMAE Hospital de Gineco Obstetricia No. 4 “Luis Castelazo Ayala”, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico;7. Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico;8. Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico;9. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA;10. Immunology and Infectology Research Unit, Infectology Hospital, Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico;11. Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán” (INCMNSZ), Mexico City, Mexico |
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| Abstract: | ![]()
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 636 Mexicans from the state of Oaxaca living in the city of Oaxaca (N = 151) and rural communities (N = 485), to obtain information regarding allelic and haplotypic frequencies. We found that the 13 most frequent haplotypes in Oaxaca are all of putative Native American origin. Admixture estimates revealed that the main genetic components in the state of Oaxaca are Native American (73.12 ± 2.77% by ML; 61.52% of Native American haplotypes) and European (17.36 ± 2.07% by ML; 20.69% of European haplotypes), and a relatively high African genetic component (9.52 ± 0.88% by ML; 8.94% of African haplotypes). |
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| Keywords: | HLA Immunogenetics Population genetics Oaxaca Admixture |
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