药物肠道吸收研究方法概述

口服药物肠道吸收的研究方法主要包括体外法、体内法和在体法，对这3种研究方法进行简要介绍。鉴于在体肠灌流法操作简便、技术成熟、可控性强，同时又保证了神经内分泌调节与淋巴液血液供应的完整性等特点，更能反映药物吸收的真实情况，因此重点介绍了在体肠灌流法，并对在体肠灌流法中使用的循环灌流法和单向灌流法常用的几种灌流液体积校正方法等进行综述，为研究口服药物肠道吸收试验设计提供借鉴和参考。为保证试验的可操作性和实验结果的准确性，认为应根据所研究药品的性质、实验要求、试验条件等多方面因素综合考虑，选择适宜的试验方法，进而为药物剂型的开发和临床合理用药提供依据。

Summary of research methods for drug intestinal absorption

At present, the study of intestinal absorption of oral drugs mainly includes in vitro, in vivo and in situ methods. In view of the advantages of in situ intestinal perfusion such as simple operation, mature technology, controllable, ensure the neuroendocrine regulation and blood supply, and so on, which could better reflect the true situation of drug absorption. In this study, the research methods and characteristics of intestinal absorption of oral drugs were systematically introduced. The recirculating perfusion method and single-pass perfusion method were compared, and several volume correction methods were also introduced. In order to ensure the operability and accuracy of experimental results, proper experiment method of intestinal absorption will be adopt according to the factors such as drug characters, experiment requirements, experimental conditions, and so on. The article provides a scientific basis for the development of pharmaceutical dosage and clinical rational drug use.