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| 基质金属蛋白酶3基因多态性与动脉粥样硬化的研究进展 | |
| 引用本文： | 黄小亚,金笑平. 基质金属蛋白酶3基因多态性与动脉粥样硬化的研究进展[J]. 医学综述, 2008, 14(17): 2600-2603 |
| 作者姓名： | 黄小亚 金笑平 |
| 作者单位： | 浙江省温州医学院附属台州医院神经内科,浙江,台州,317000 |
| 摘 要： | 基质金属蛋白酶3(MMP-3,又称基质细胞溶解酶1)是人体内最重要的蛋白酶之一。它对多种细胞外基质有蛋白水解作用,参与人体许多病理和生理过程。目前报道的关于MMP-35A/6A基因多态性和动脉粥样硬化的关系,仍存在争议。文章就MMP-35A/6A基因多态性与冠状动脉及颈动脉粥样硬化的关系予以综述。 |
| 关 键 词： | 基质金属蛋白酶3 基质细胞溶解酶 动脉粥样硬化 基因多态性 |
Progress about Polymorphism of Matrix Metalloproteinase3 (5A/6A) and Atherosclerosis |
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| HUANG Xiao-ya,JIN Xiao-ping. Progress about Polymorphism of Matrix Metalloproteinase3 (5A/6A) and Atherosclerosis[J]. Medical Recapitulate, 2008, 14(17): 2600-2603 | |
| Authors: | HUANG Xiao-ya JIN Xiao-ping |
| Affiliation: | HUANG Xiao-ya,JIN Xiao-ping.(Department of Neurology,Taizhou Hospital,Wenzhou Medical College,Zhejiang 317000,China) |
| Abstract: | Matrix metalloproteinase3(MMP-3,also named stromelysin1)is one of the most important proteinases of the body.It has proteolytic activity on a number of extracellular matrix proteins,participates in many pathological and physiological processes.There still is controversy about the relationship with polymorphism of MMP-3 5A/6A and atherosclerosis.This article reviews the relationship of polymorphism of MMP-3 5A/6A with atherosclerosis of aeteria coronaria and carotid. |
| Keywords: | Matrix metalloproteinase3 Stromelysin Atherosclerosis Gene polymorphism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |