白藜芦醇在绝经后骨质疏松症中抗氧化机制的研究进展

绝经后骨质疏松症(PO)是一种全身性骨骼疾病,由雌激素缺乏和衰老引起,其特征是低骨密度(BMD)和骨组织的微结构恶化,并导致骨质疏松性骨折的风险增高。在PO的发生发展过程中,潜在的致病机制是复杂和多方面的,雌激素缺乏是骨吸收增加和骨质流失加速的重要原因。同时,由于雌激素的缺乏和机体的衰老导致氧化应激(OS)水平的升高,是PO发生的主要机制之一。针对老年绝经后骨质疏松患者的治疗目前较为有效的是采用雌激素替代疗法,但也增加了患乳腺癌、子宫癌和心血管事件发生的风险。因此,寻找有效的抗氧化应激药物以治疗PO受到了越来越多研究者的关注。其中以白藜芦醇(RES)为代表的天然植物化合物,是一种具有抗氧化和抗衰老作用的天然抗氧化剂。它能通过多种通路抑制体内氧化应激,促进成骨分化和减少骨量丢失,并调节骨转换的能力,从而有效治疗PO。本文就白藜芦醇在PO中的抗氧化机制及其研究进展做一综述。

Advances in research on antioxidant mechanism of resveratrol in postmenopausal osteoporosis

Postmenopausal osteoporosis (PO) is a systemic bone disease caused by estrogen deficiency and aging, which is characterized by low bone mineral density (BMD) and microstructural deterioration of the bone tissue, leading to the increase of osteoporotic fracture risk. In the development of PO, the underlying pathogenesis is complex and multi-faceted. Estrogen deficiency is an important cause of increased bone resorption and accelerated bone loss. At the same time, the lack of estrogen and the aging of the body lead to an increase in oxidative stress (OS) levels, which is one of the main mechanisms of PO. Treatment of elderly postmenopausal osteoporosis is currently more effective with estrogen replacement therapy, but it also increases the risk of breast cancer, uterine cancer, and cardiovascular events. Therefore, the search for effective anti-oxidative stress drugs to treat PO has attracted the attention of more and more researchers. The natural plant compound represented by resveratrol (RES) is a natural antioxidant with anti-oxidation and anti-aging effects. It can effectively treat PO through a variety of pathways to inhibit oxidative stress in the body, promote osteogenic differentiation and reduce bone loss, and regulate bone turnover. In this paper, the anti-oxidation mechanism of resveratrol in PO and its research progress are reviewed.