德阳地区37799例宫颈人乳头瘤病毒流行病学调查分析

目的了解德阳地区人乳头瘤病毒(human papilloma virus, HPV)感染亚型分布情况、多重感染率以及与年龄的相关性,为宫颈癌防治提供参考依据。方法回顾性分析2015年2月至2019年7月于德阳市人民医院就诊的37 799例妇女宫颈样本(脱落细胞及石蜡组织),采用聚合酶链式反应(polymerase chain reaction, PCR)-反向点杂交法对其进行分型。结果就诊妇女HPV感染率为27.25%,其中低危型感染率8.24%,高危型感染率22.68%,排名前5的HPV基因型依次为52、16、81、58、53。单一型感染占总感染人数的71.61%,是HPV感染的主要模式;二重感染占19.56%,三重及以上感染占8.83%。HPV感染与年龄相关,高危感染率、低危感染率、阳性率、多重感染率的高峰在20岁以下,60岁以上。结论应加强对小于20岁,大于60岁女性的健康教育,提高其对HPV的认识,加大宫颈癌筛查力度。

Epidemiological investigation and analysis of 37799 cases of the cervical human papillomavirus in Deyang district

Objective To understand the distribution of human papilloma virus(HPV) infection subtypes, multiple infection rates and the correlation with age among the patients in Deyang district, so as to provide reference for the prevention and treatment of cervical cancer. Methods A total of 37 799 cervical samples(shed cells and paraffin tissues) in People’s Hospital of Deyang City from Febmary 2015 to July 2019 were collected and classified by polymerase chain reaction(PCR)-reverse point hybridization.Results The HPV infection rate of women detected was 27.25 %, among which the low-risk type infection rate was 8.24 %, the high-risk type infection rate was 22.68 %, and the top five HPV genotypes were 52,16,81,58,53.Single infection accounted for 71.61 % of the total infected people, which was the main pattern of HPV infection, with double infection accounting for 19.56 % and triple or above infection accounting for 8.83 %.HPV infection was related to age.The peak of high-risk infection rate, low-risk infection rate, positive rate and multiple infection rate was under 20 years old and over 60 years old.Conclusion Health education should be strengthened for women younger than 20 years old and older than 60 years old to increase their awareness of HPV and increase cervical screening.