不同年龄阿尔茨海默病患者脑核团ADC值与年龄的相关性

目的 探讨不同年龄阿尔茨海默病（AD）患者ADC值与年龄的相关性。方法 选取30例AD患者（AD组）和年龄与之相匹配的30名志愿者（对照组），按年龄段各分为6个亚组55~59岁（n=3）、60~64岁（n=4）、65~70岁（n=9）、71~74岁（n=5）、75~80岁（n=6）、>80岁（n=3）]，测量双侧海马、红核、尾状核、杏仁体、壳核ADC值，并进行配对t检验、独立样本t检验、单因素方差分析及Pearson相关分析。结果 AD组红核左、右侧ADC值有统计学差异（P=0.022）。AD组不同年龄亚组右侧海马、双侧尾状核、右侧壳核ADC值差异有统计学意义（P均<0.05）；2组不同年龄亚组双侧海马、壳核、尾状核ADC值差异有统计学意义（P均<0.05）。AD组右侧海马（r=0.615，P<0.001）、右侧壳核（r=0.653，P=0.001）及双侧尾状核（左侧：r=0.397，P=0.030；右侧：r=0.429，P=0.020）ADC值与年龄呈正相关。结论 AD患者右侧海马和壳核、双侧尾状核ADC值随年龄增加而增大。ADC值可为临床预测和早期诊断AD脑内右侧海马和壳核、双侧尾状核神经退行性病变提供参考。

Correlation between ADC value of cerebral nuclei and age in different aged Alzheimer disease patients

Objective To explore the correlation between ADC value of cerebral nuclei and age in patients with Alzheimer disease (AD) with different ages. Methods Thirty AD patients (AD group) and 30 matched volunteers (control group) were enrolled and divided into 6 subgroups according to age (55-59 years old, 60-64 years old, 65-70 years old, 71-74 years old, 75-80 years old,>80 years old). ADC values of left and right hippocampus, red nucleus, caudate nucleus, amygdala and putamen were measured. The paired t-test, independent sample t-test, one-way ANOVA and Pearson correlation analysis were performed. Results There were significant differences of ADC values between left and right red nucleus in AD group (P=0.022), also of ADC values in right hippocampus, bilateral caudate nucleus and right caudate nucleus in different age subgroups of AD group (all P<0.05). There were significant differences of ADC values in bilateral hippocampus, putamen and caudate nucleus among different subgroups of AD group and control group (all P<0.05). Positive correlations of age and right hippocampus (r=0.615, P<0.001), right putamen (r=0.653, P=0.001) and bilateral caudate nucleus (left:r=0.397, P=0.030; right:r=0.429, P=0.020) were found in AD group. Conclusion ADC values in bilateral hippocampus, putamen and caudate nucleus of AD patients increase with age. ADC values can provide references for clinical prediction and early diagnosis of neurodegenerative lesions in bilateral hippocampus, putamen and caudate nucleus of AD brain.