| 童乐口服液对哮喘大鼠的干预研究 |
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| 作者姓名： | 杨涛 何开勇 汪杨 刘晓锋 |
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| 作者单位： | 1.湖北中医药大学附属荆州市中医医院，湖北 荆州 434000,2.湖北省药品监督检验研究院，湖北 武汉 430071,2.湖北省药品监督检验研究院，湖北 武汉 430071,2.湖北省药品监督检验研究院，湖北 武汉 430071 |
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| 基金项目： | 湖北省卫生计生委课题（No.2013Z-Y41） |
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| 摘 要： | 目的 探讨童乐口服液对哮喘大鼠的干预作用及机制。方法 通过卵蛋白激发诱导建立大鼠哮喘模型，以孟鲁司特钠为阳性对照，用不同剂量的童乐口服液进行干预，用化学发光法检测血清中免疫球蛋白IgE和白介素（IL-4、IL-10）。结果 经童乐口服液灌胃给药后，哮喘大鼠免疫球蛋白IgE和白介素（IL-4、IL-10）与模型组有显著差异（P<0.05），与正常对照组无显著差异（P>0.05）。结论 童乐口服液可显著性降低哮喘大鼠的IgE和IL-4水平，升高IL-10的水平，抗炎机理可能与抑制Th2 类细胞因子的活性有。
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| 关 键 词： | 童乐口服液 免疫球蛋白E 白细胞介素（IL-4、IL-10） |
Study of the intervention effect of Tongle Oral Liquid on asthmatic rats |
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| Authors: | YANG Tao HE Kaiyong WANG Yang and LIU Xiaofeng |
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| Institution: | 1.Jinzhou Hospital of Traditional Chinese Medcine Affiliated to Hubei University of Chinese Medicine,Jingzhou 434000,China;2.Hubei Institute for Drug Control,Wuhan 430071,China,1.Jinzhou Hospital of Traditional Chinese Medcine Affiliated to Hubei University of Chinese Medicine,Jingzhou 434000,China;2.Hubei Institute for Drug Control,Wuhan 430071,China,1.Jinzhou Hospital of Traditional Chinese Medcine Affiliated to Hubei University of Chinese Medicine,Jingzhou 434000,China;2.Hubei Institute for Drug Control,Wuhan 430071,China and 1.Jinzhou Hospital of Traditional Chinese Medcine Affiliated to Hubei University of Chinese Medicine,Jingzhou 434000,China;2.Hubei Institute for Drug Control,Wuhan 430071,China |
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| Abstract: | Objective To investigate the intervention effect and mechanism of Tongle Oral Liquid on asthmatic rats.Methods The rat model of asthma was induced by ovalbumin.The immunoglobulin IgE and interleukin (IL-4, IL-10) in serum were detected by chemiluminescence methods. The asthmatic rats were treated with different doses of Tongle Oral Liquid, using the montelukast sodium as the positive control.Results The immunoglobulin IgE and interleukin (IL-4,IL-10) in asthmatic rats were significantly different between intragastric administration groups and the model group (P<0.05).Compare with the normal control group, the expression level of IgE and interleukin (IL-4,IL-10) was not significantly different in intragastric administration groups(P>0.05).Conclusion Tongle Oral Liquid could significantly reduce the level of IgE and IL-4 in asthmatic rats and increase the level of IL-10.The mechanism of inflammation may be related to inhibiting the activity of Th2 cytokines. |
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| Keywords: | Tongle Oral Liquid Immunoglobulin IgE Interleukin (IL-4 IL-10) |
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