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| 何首乌吸收动力学研究进展 | |
| 引用本文： | 周忆梦,全云云,李芸霞. 何首乌吸收动力学研究进展[J]. 药学研究, 2019, 38(3): 163-166 |
| 作者姓名： | 周忆梦 全云云 李芸霞 |
| 作者单位： | 成都中医药大学药学院，中药材标准化教育部重点实验室，中药资源系统研究与开发利用省部共建国家重点实验室培育基地，四川 成都 611137,成都中医药大学药学院，中药材标准化教育部重点实验室，中药资源系统研究与开发利用省部共建国家重点实验室培育基地，四川 成都 611137,成都中医药大学药学院，中药材标准化教育部重点实验室，中药资源系统研究与开发利用省部共建国家重点实验室培育基地，四川 成都 611137 |
| 基金项目： | 国家自然科学基金面上项目（No.81373943、81573583）；四川省科技厅省青年科技创新研究团队专项计划项目（No.2016TD0028、2017TD0001） |
| 摘 要： | 何首乌作为传统常用中药，被广泛应用于临床，在疾病治疗中发挥重要作用。临床上，何首乌饮片及制剂主要以口服为主，所含化学成分被吸收进入机体并与机体相互作用是其发挥药效的前提，因此，研究何首乌的吸收机制具有重要意义。本文通过查阅文献，对何首乌主要成分的吸收动力学研究进行综述，以期为评价何首乌的生物利用度、改善剂型、提高药效提供参考。 |
| 关 键 词： | 何首乌；二苯乙烯苷；蒽醌类成分；吸收动力学 |
Research progress on absorption of Polygonum multiflorum |
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| ZHOU Yimeng,QUAN Yunyun and LI Yunxia. Research progress on absorption of Polygonum multiflorum[J]. Journal of Pharmaceutical Research, 2019, 38(3): 163-166 | |
| Authors: | ZHOU Yimeng QUAN Yunyun LI Yunxia |
| Affiliation: | School of Pharmacy, Chengdu University of Traditional Chinese Medicine,Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education,National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources,Chengdu 611137,China,School of Pharmacy, Chengdu University of Traditional Chinese Medicine,Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education,National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources,Chengdu 611137,China and School of Pharmacy, Chengdu University of Traditional Chinese Medicine,Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education,National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources,Chengdu 611137,China |
| Abstract: | As a traditional Chinese medicine, Polygonum multiflorum (PM) is widely used in clinical practice and plays an important role in the treatment of diseases. Clinically, PM are mainly oral administration, and the effect of the drug is based on that the chemical components are absorbed into the body and interact with the body. Therefore, it is significant to study the absorption mechanism of PM.In this paper, the absorption kinetics of the main components of PM were summarized, and it was expected to provide a reference for the evaluation of the bioavailability of PM, improve the dosage form, and improve the efficacy. |
| Keywords: | Polygonum multiflorum Stilbene glycosides Anthraquinones Pharmacokinetics of absorption |
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