血清C1q/肿瘤坏死因子相关蛋白3水平与冠心病患者介入治疗后心血管不良事件发生的关系

［摘要］ 目的 探讨分析C1q/肿瘤坏死因子相关蛋白3（CTRP3）水平与冠心病患者经皮冠状动脉介入（PCI）治疗后心血管不良事件发生的关系。方法 选取2016年6月至2017年6月胸痛中心收治的107 例接受介入治疗的冠心病患者作为研究对象，常规留置所有患者治疗前的血样，依据术后半年不良事件的发生情况进行分组，将发生不良事件的42例患者设为观察组，将未发生不良事件的65例患者设为对照组，收集术后半年两组患者的血样，比较两组患者治疗前和术后半年C1q/肿瘤坏死因子相关蛋白3（CTRP3）及C反应蛋白（CRP）、白介素10（IL?10）、肿瘤坏死因子α（TNF?α）等炎症因子水平的变化。结果 观察组治疗前CTRP3、IL?10水平低于对照组，TNF?α、CRP水平高于对照组（P<0.05），而两组IL?6水平比较差异不显著（P>0.05），介入治疗术后半年观察组血清CTRP3、IL?10水平仍低于对照组，CRP高于对照组（P<0.05），两组间TNF?α及IL?6水平没有显著差异（P>0.05）；且两组患者TNF?α、CRP、IL?6的水平均高于介入治疗前；相关性分析结果显示CTRP3水平和IL?10水平呈现出正相关（r=0.615，P<0.001），和CRP 水平呈现出负相关（r=-0.737，P<0.001）。结论 C1q/肿瘤坏死因子相关蛋白3与冠心病患者介入治疗后心血管不良事件发生可能存在负相关性，CTRP3水平越低，心血管不良事件的发生率越高。

Relationship between serum levels of C1q/TNF?related protein 3 and cardiovascular adverse events after interventional therapy in patients with coronary heart disease

［Abstract］ Objective To investigate the relationship between C1q/TNF?related protein 3 （CTRP3） levels and cardiovascular adverse events after percutaneous coronary intervention（PCI） in patients with coronary heart disease. Methods 107 patients with coronary heart disease after PCI admitted to the department of cardiology from June 2016 to June 2017 were selected， regularly indwelling all patients with blood samples before treatment. According to the occurrence of adverse events within half a year after surgery， 42 patients with adverse events were selected as the observation group， and 65 patients without adverse events were selected as the control group， blood samples from the two groups of patients after half a year the operation were collected. The changes of inflammatory factors such as C1q/TNF?related protein 3 （CTRP3）， C?reactive protein （CRP）， interleukin?10 （IL?10） and tumor necrosis factor?α （TNF?α） were compared between the two groups before and after half a year treatment. Results The levels of CTRP3 and IL?10 in the observation group were significantly lower than those in the control group， the levels of TNF?α and CRP in the observation group were significantly higher than those in the control group （P<0.05） before treatment， but the levels of IL?6 in the two groups were not significantly different （P>0.05）. The levels of serum CTRP3 and IL?10 in the observation group after half a year treatment were lower than those in the control group， and CRP was higher than that in the control group （P<0.05）， there was no significant difference in TNF?α and IL?6 levels between the two groups （P>0.05）， and the levels of TNF?α， CRP， and IL?6 are higher than before intervention in both two group. Correlation analysis result showed that there is a positive correlation between CTRP3 and IL?10 levels （r=0.615， P<0.001）， and a negative correlation with CRP levels （r=-0.737， P>0.001）. Conclusion There may be a negative correlation between CTRP3 and cardiovascular adverse events after interventional therapy in patients with coronary heart disease. The lower the level of CTRP3， the higher the incidence of cardiovascular adverse events. Therefore， it is of great clinical significance to regularly detect CTRP3 levels in patients undergoing coronary stent implantation.