蛋白及多肽类药物长效化制剂学技术研究进展

蛋白及多肽类药物近年来越来越多地应用到疾病的预防、诊断和治疗之中，然而，蛋白及多肽类药物通常需要注射给药且缺乏长效剂型，给需要长期用药的慢性病患者带来困扰。本文综述了通过制剂学手段对蛋白及多肽类药物进行长效化改造的策略，包括缓释注射剂、植入剂、口服制剂以及经皮给药系统，并总结其缓释机制、研究进展和优缺点，以期为此类药物的剂型改良提供研究思路及理论参考。

Progress in technology of long-acting preparations of protein and peptide drugs

As one of the most important biological drugs, protein and peptide drugs have been increasingly used in the prevention, diagnosis and treatment of diseases in recent years. However, most of them need to be injected and lack of long-acting formulations, which brings many troubles to patients suffering from chronic diseases. In this review, we summarized the strategies for engineering long-acting formulations for proteins and peptides via preparation means, including extended-release injection, implant, oral preparations and transdermal drug delivery systems, and analyzed their release mechanisms, research advances, advantages and shortcomings, thereby providing potential approaches for promoting the formulation improvement of these drugs.