生脉注射液对阻塞性黄疸术后炎症介质及肾功能作用的研究

目的：观察生脉注射液对阻塞性黄疸（阻黄）术后炎症介质及肾功能的作用。方法：阻黄及非黄疸的肝外科患者分三组，术后给予一般治疗阻黄（OJ）组、非黄疸（NON－LJ）组及生脉注射液治疗阻黄组。动态观察血浆炎症介质内毒（LPs）、肿瘤坏死因子（TNF－α）、白细胞介素－6，8（IL－6，IL－8）、内皮素（ET）以及肾脏功能指标尿转铁蛋白（TFR）、尿白蛋白（ALB）及尿视黄醇（RBP）的变化。结果：生脉主射液治疗组术后7天与术后1天相比，LPs、IL－6、IL－8、ET、TNF－α、TFR、RBP、ALB明显下降（P＜0．05），且低于或接近术前水平，黄疸对照组在术后7天与术后1天相比无显著差异（P＞0．05）。结论：生脉注射液对阻黄患者术后LPs有拮抗作用，同时降低其它炎症介质水平，另外 具有保护肾脏功能的作用。

CLINICAL STUDY OF SHENGMAI INJECTION ON INFLAMMATORY MEDIATOR AND RENAL INJURY OF POST-OPERATIVE PATIENTS WITH OBSTRUCTIVE JAUNDICE

OBJECTIVE:To investigate the effect of Shengmai injection on inflammatory mediator and renal injury in obstructive jaundice.METHODS:The patients with obstructive jaundice were randomly divided into 2 groups. 15 cases of non-jaundiced patients as another control group according to preoperative arrangement. The plasma ET, LPs, TNF-а, IL-6, IL-8 and urine RBP, TFR, ALB were measured pre and post operative 1, 4, 7 days.RESULTS:LPs , TNF-а, IL-6, IL-8, ET, RBP, TFR and ALB level of Shengmai injection group during post-operative 7 day were obviously lowered as compared with the same group during post-operative 1 day(P<0.05).CONCLUSION:post-operative uses of Shengmai injection might effectively decrease the post-operative level of plasma LPs, ET, TNF-α and IL-6，IL-8. At the mean time, Shengmai injection may protect renal function by inhibiting inflammatory mediator and improving blood dynamics.