Effect of Two Kinds of Different Combined Oral Contraceptives Used on Bone Mineral Density in Women of Reproductive Age

Objective To compare bone mineral density (BMD) among users of ethinylestradiol/desogestrel,ethinylestradiol/cyproterone acetate and nonhormonal control subjects.Methods The study included 154 women aged 25-40 years.Forty-six women were using ethinylestradiol/desogestrel (group A) and 55 women using ethinylestradiol/cyproterone acetate (group B) for 24 months and 53 women using nonhormonal contraception as control subjects (group C).BMD of the lumbar spine and femoral neck were obtained using dual energy X-ray absorptiometry,comparing mean BMD changes in combined oral contraceptives (COCs) users with nonusers.Results For 24 months of treatment,lumbar spine and femoral neck BMD values in women who used ethinylestradiol/desogestrel and ethinylestradiol/cyproterone acetate were not significantly different compared with the baseline and the values of subjects in nonuser (P＞O.05).Conclusion There was no statistical difference in BMD between the users of ethinylestradiol/desogestrel or ethinylestradiol/cyproterone acetate and nonusers.