硫氧还蛋白基因TXN单核苷酸多态性与中国汉族人群肺癌易感性研究

目的 探讨硫氧还蛋白基因TXN的单核苷酸多态性与肺癌易感性间的关系.方法 采集经病理组织学确诊的肺癌患者292例,相同地区、性别、年龄频数匹配的体检健康对照307例,针对筛选出的TXN基因9个单核苷酸多态性(SNP)位点进行基因型检测,通过统计分析研究基因频率与肺癌风险的关系,并探讨吸烟在其中的影响.结果 3个TXN基...

Study on single nucleotide polymorphism of thioredoxin gene TXN and lung cancer susceptibility in Chinese Han population

Objective To assess the relationship between single nucleotide polymorphism(SNP) of thioredoxin gene TXN and the susceptibility of lung cancer in Chinese Han population. Methods A case control study on 292 cases with histologically confirmed lung cancer and 307 age and gender matched cancer free controls of Chinese Han population was performed. The selected 9 SNP sites were genotyped by PCR with iPLEX technique. Results Significant differences of the frequency were observed in 3 SNP of TXN gene: rs2776, rs4135220 and rs4135212 between lung cancer paitients and controls. The subjects who carried mutated alleles on rs2776 rs4135220 showed a 0.77 times increase of lung cancer risk (95%CI=1.10 2.84), while a 1.24 times increase of risk for those who carried mutation on rs4135212 (95%CI=1.29 3.89) in a dominant model. An increased risk for lung cancer was observed in stratification analysis for smoking quantity. Low grade smokers carrying rs2776 rs4135220 mutation showed a 0.75 times increase of lung cancer risk (95%CI=1.01-3.04) and a 1.46 times increase (95%CI=1.29-3.04) for those who carried rs4135212 mutation. Conclusions The results of this study support that the SNP of rs2776, rs4135220 and rs4135212 in TXN gene may associate with lung cancer susceptibility in Chinese Han population. The lung cancer risk may rise in non smokers and low grade smokers carrying mutations on the 3 SNP sites.