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脊柱转移性肿瘤的手术治疗及疗效分析
引用本文:叶曙明,齐新生,茅治湘,王全明,韦学昌. 脊柱转移性肿瘤的手术治疗及疗效分析[J]. 中国骨伤, 2011, 24(12): 977-981. DOI: 10.3969/j.issn.1003-0034.2011.12.002
作者姓名:叶曙明  齐新生  茅治湘  王全明  韦学昌
作者单位:苏州大学附属第四医院骨科,江苏无锡,214062
摘    要:目的:探讨脊柱转移性肿瘤的手术治疗方法和疗效。方法:回顾性分析自2005年9月至2010年8月收治的36例接受手术治疗的脊柱转移性肿瘤患者的临床资料,其中男15例,女21例;年龄27~79岁,平均58岁。原发灶来源分别为乳腺癌、肺癌、前列腺癌、结肠癌、肝癌、食管癌、肾癌、膀胱癌,10例原发灶来源不明。肿瘤分布部位:颈椎5例,胸椎17例,腰椎13例,骶椎1例。根据Tokuhashi脊柱转移瘤的预后评分系统:0~8分9例,9~11分25例,12~15分2例。根据术前Tokuhashi评分,肿瘤侵犯的节段、范围和有无神经症状选择单纯经皮椎体成形术(percutaneous vertebroplasty,PVP)或肿瘤切除椎管减压内固定术;椎体功能重建采用钛网植入、人工椎体置换、骨水泥填塞等方法。手术前后对患者的疼痛、脊髓功能及体力状况进行评估并对患者术后3、6个月及1、2年的生存率进行观察。结果:随访2~60个月,平均10.8个月。患者术后疼痛较术前减轻或消失(P〈0.05)。14例脊髓损伤的患者术后Frankel分级评估:12例分别提高1~2级。术后体力状况ECOG分级评估:28例分别提高1~2级。患者术后3、6个月及1、2年生存率分别为97.2%、63.9%、38.9%和16.7%。骨水泥渗漏6例,无严重手术并发症发生。结论:依据单发或多发转移、有无神经功能损害和脊柱失稳、全身状况选择不同的手术方法治疗脊柱转移性肿瘤,可明显减轻患者疼痛,维持和改善神经功能,改善患者生存质量,提高患者生存率。

关 键 词:脊柱  肿瘤转移  外科手术  回顾性研究
收稿时间:2011-08-29

Analysis of surgical treatment and effect of spinal metastatic tumors
YE Shu-ming,QI Xin-sheng,MAO Zhi-xiang,WANG Quan-ming and WEI Xue-chang. Analysis of surgical treatment and effect of spinal metastatic tumors[J]. China journal of orthopaedics and traumatology, 2011, 24(12): 977-981. DOI: 10.3969/j.issn.1003-0034.2011.12.002
Authors:YE Shu-ming  QI Xin-sheng  MAO Zhi-xiang  WANG Quan-ming  WEI Xue-chang
Affiliation:Department of Orthopaedics Surgery, the Fourth Hospital Affiliated to Suzhou University, Wuxi 214062, Jiangsu, China;Department of Orthopaedics Surgery, the Fourth Hospital Affiliated to Suzhou University, Wuxi 214062, Jiangsu, China;Department of Orthopaedics Surgery, the Fourth Hospital Affiliated to Suzhou University, Wuxi 214062, Jiangsu, China;Department of Orthopaedics Surgery, the Fourth Hospital Affiliated to Suzhou University, Wuxi 214062, Jiangsu, China;Department of Orthopaedics Surgery, the Fourth Hospital Affiliated to Suzhou University, Wuxi 214062, Jiangsu, China
Abstract:Objective:To investigate clinical outcome of surgical treatment for spinal metastatic tumors.Methods:Thirty-six patients with metastatic spine tumors treated surgically were retrospectivly reviewed from September 2005 to August 2010.There were 15 males and 21 females with an average age of 58 years old(ranged,27 to 79 years).The site of origin of primary cancer included the breast,prostate,colon,lung,liver,esophagus,kidney,carcinoma,bladder,and 10 patients were with unidentified primary cancer.Five lesions ...
Keywords:Spine  Neoplasm metastasis  Surgical procedures,operative  Retrospective studies
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