核苷酸切除修复通路基因多态性与肺癌易感性

Gene polymorphisms in the nucleotide excision repair pathway and lung cancer susceptibility

Nucleotide excision repair (NER) pathway is one of the principal ways of the repair of DNA damage. The single nucleotide polymorphisms (SNP) of its key genes such as xeroderma pigmentosum group A (XPA) gene, excision repair cross complementing1 (ERCC1) gene and xeroderma pigmentosum group D (XPD) gene may be associated with differences in the DNA repair capacity and may influence an individual’s risk of lung cancer, because the variant genotype in those polymorphisms might destroy or alter repair function.