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Vanilloids induce oral cancer apoptosis independent of TRPV1
Affiliation:1. Cancer Therapy and Research Center, UTHSCSA, San Antonio, TX 78229, USA;2. Comprehensive Dentistry, UTHSCSA Dental School, San Antonio, TX 78229, USA;3. Molecular Medicine, UTHSCSA, San Antonio, TX 78229, USA;4. Endodontics, UTHSCSA Dental School, San Antonio, TX 78229, USA;5. Pharmacology, UTHSCSA Dental School, San Antonio, TX 78229, USA;1. Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea;2. National Leading Research Laboratory of Molecular Modeling & Drug Design, College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea;3. Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA;1. Anesthesia Section, Department of Perioperative Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland;2. Molecular Genetics Unit, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, Bethesda, Maryland;3. Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland;1. Department of Pharmacy, Faculty of Pharmaceutical Science, University of São Paulo (USP), Av. Prof. Lineu Prestes, 580, São Paulo, SP 5508-000, Brazil;2. Biochemistry and Biophysical Laboratory, Butantan Institute, Av. Vital Brasil, 1500, São Paulo, SP 05503-900, Brazil;3. Department of Pharmacy, University of Copenhagen, Universitetsparken, 2, 2100 Copenhagen, Denmark;4. Laboratory of Tumor Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (SP), Av. Prof. Lineu Prestes, 1730, São Paulo, SP 05508-900, Brazil;5. Faculdade de Física, Universidade Federal do Pará (UFPA), Campus de Marabá, Folha 17, Quadra 04, Lote Especial, Nova Marabá, Marabá, PA 68501-970, Brazil;6. Laboratory of Genetics, Butantan Institute, Av. Vital Brasil, 1500, São Paulo, SP 05503-900, Brazil;7. Cell and Molecular Therapy Center NUCEL/NETCEM, Faculty of Medicine, University of São Paulo (USP), Rua Pangaré, São Paulo, SP 05360-120, Brazil;8. Center of Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Av. dos Estados, 5001, Santo André, SP 09210-580, Brazil;1. Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Wexner Medical Center, Columbus, OH, USA;2. Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Wexner Medical Center, Columbus, OH, USA;1. Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany;2. Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University Faculty of Medicine, Israel;3. The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel
Abstract:
Keywords:Oral cancer  TRPV1  Apoptosis  Capsaicin  Capsazepine  capsaicin"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0035"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  CAP  capsazepine"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0045"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  CPZ  oral squamous cell carcinoma"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0055"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  OSCC
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