Differential effects of cadmium administration on peripheral blood granulocytes in rats |
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| Affiliation: | 1. Department of Ecology, Institute for Biological Research “Sinisa Stankovic”, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia;2. Institute of Pathology, Military Medical Academy, University of Belgrade, Crnotravska 17, 11000 Belgrade, Serbia;3. Institute of Zoology, Faculty of Biology, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia;4. Institute of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia;1. Key Laboratory of Environmental Medicine and Engineering; Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China;2. Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, China;3. Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China;1. Ataturk University, Science Faculty, Department of Molecular Biology and Genetics, 25240 Erzurum, Turkey;2. Ataturk University, Science Faculty, Department of Chemistry, 25240 Erzurum, Turkey;1. Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India;2. Department of Pathology, Rajah Muthiah Medical College, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India;3. Department of Surgery, Rajah Muthiah Medical College, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India;1. Dongnam Institute of Radiological & Medicine Sciences, Busan 619-953, Republic of Korea;2. Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea;3. Department of Food and Nutrition, College of Human Ecology, Dongeui University, Busan 614-714, Republic of Korea;4. Anti-Aging Research Center & Blue-Bio Industry RIC, Dongeui University, Busan 614-714, Republic of Korea;5. Department of Urology, Chungbuk National University College of Medicine, Cheongju 361-763, Republic of Korea;6. Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614-052, Republic of Korea |
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| Abstract: | ![]()
Infiltration of circulatory inflammatory cells is a common histopathological finding in target organs following cadmium administration, but there is paucity of data concerning their activity. In this study, the effects of sublethal (1 mg/kg) cadmium on peripheral blood polymorphonuclear (PMN) cells were examined 48 h following administration in rats, when tissue (liver and lung) infiltration of these cells was observed. Cadmium administration resulted in systemic inflammatory cytokine and acute phase response with an increase in circulatory neutrophil numbers and cells that express CD11b molecules. Rise in basic aspects of oxidative activity including intracellular myeloperoxidase (MPO), reactive oxygen (nitroblue tetrazolium/NBT cytochemical assay) and nitrogen (Griess assay) species production was observed in PMNs from cadmium-administered rats. A decrease in levels of mRNA for IL-1β, TNF-α and IL-6 was noted, but production of these cytokines was affected differentially. Described effects of cadmium on PMNs add further to the understanding of inflammatory potential of this environmental contaminant. |
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| Keywords: | Intraperitoneal cadmium administration Rat Systemic inflammatory cytokine and acute phase response Peripheral blood polymorphonuclear leukocyte (PMN) Oxidative activity Inflammatory cytokines (IL-1β, TNF-α, IL-6) |
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