Evaluation of efficacy of natural astaxanthin and vitamin E in prevention of colistin-induced nephrotoxicity in the rat model |
| |
| Institution: | 1. Canakkale Onsekiz Mart University Faculty of Medicine, Department of Cardiology, Canakkale, Turkey;2. Canakkale Onsekiz Mart University Faculty of Medicine, Department of Medical Biochemistry, Canakkale, Turkey;3. Memorial Bahcelievler Hospital, Department of Cardiology, Istanbul, Turkey |
| |
| Abstract: | ObjectiveWe evaluated the effect of astaxanthin (ASX) and vitamin E (vit E) on colistin methanesulfonate (CMS) induced-nephrotoxicity in rats.MethodsAnimals were treated with sterile saline, 300 000 or 450 000 IU/kg/day of CMS, CMS + ASX (20 mg/kg), CMS + vit E (100 mg/kg), or CMS + 1 ml/kg olive oil (OO) for 7 days. The plasma/urine creatinine (Cr) level, urine γ-glutamyl-transferase (GGT) level, and renal tissue activities in malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reductase (GSH), as well as renal histology were performed.ResultsCMS induced a tubular damage, increased the GGT and MDA levels, and decreased the activities of SOD, CAT, GPx and GSH. Co-treatment with ASX or vit E restored all biochemical parameters cited above and improved the histopathological damage.ConclusionNephrotoxicity induced by CMS might be due to oxidative damage. The improvement by ASX or vit E seems to be related to their antioxidant properties. |
| |
| Keywords: | Colistin Nephrotoxicity Oxidative damage Astaxanthin Vitamin E |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
