Toxic effects of zearalenone on oxidative stress,inflammatory cytokines,biochemical and pathological changes induced by this toxin in the kidney of pregnant rats |
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| Affiliation: | 1. School of Public Health, Taishan Medical University, Taian 271000, China;2. School of Public Health, Shandong University, Jinan 250012, China;3. College of Animal Science & Veterinary Medicine, Guangxi University, Nanning 530004, China;4. Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;5. Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200025, China;1. Department of Biochemistry, School of Medicine, Nantong University, 19 Qi Xiu Rode, 226001 Nantong, China;2. Department of Biosystem Engineering, College of Biosystem Engineering and Food Science, Zhejiang University, 388 Yu Hang Tang Road, 310058 Hangzhou, China;3. Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, 388 Yu Hang Tang Road, 310058 Hangzhou, China;1. Department of Biology, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, PR China;2. Research Center of Engineering Technology for Extraction of Bioactive Compounds, Anhui Academy of Applied Technology, Suixi Road 312, 230031 Hefei, Anhui, PR China;1. Department of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224003, PR China;2. State Key Laboratory of Pollution Control and Resources Reuse, School of Environment, Nanjing University, Nanjing 210046, Jiangsu, PR China |
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| Abstract: | ![]()
An experiment was conducted to determine the toxic effects of zearalenone (ZEN) on oxidative stress, inflammatory cytokines, biochemical and pathological changes in the kidney of pregnant rats, and to explore the possible mechanism in ZEN induced kidney damage. The rats were fed a normal diet treated with 0.3, 48.5, 97.6 or 146 mg/kg ZEN in feed on gestation days (GDs) 0 through 7, and then all the rats were fed with a normal diet on GDs 8 through 20. The results showed that ZEN induced kidney dysfunction, oxidative damage, pathological changes and increased mRNA and protein expression of TLR4 and inflammatory cytokines in kidney in dose-dependent manner. The results indicated that ZEN caused kidney damage of pregnant rats and TLR4-mediated inflammatory reactions signal pathway was one of the mechanisms of ZEN mediated toxicity in kidney. |
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| Keywords: | Zearalenone Oxidative stress Biochemical and pathological changes Inflammatory cytokines Kidney Pregnant rats |
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