Sensitive measures of executive dysfunction in non-demented Parkinson's disease |
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| Affiliation: | 1. SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA;2. Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA;1. School of Kinesiology, Faculty of Health Sciences, Western University, London, ON, Canada;2. Lawson Health Research Institute, London, ON, Canada;3. Health & Rehabilitation Sciences, Faculty of Health Sciences, Western University, London, ON, Canada;4. School of Health Studies, Faculty of Health Sciences, Western University, London, ON, Canada;5. Cognitive Health and Aging Research Lab, Montreal Heart Institute, Montreal, QC, Canada;6. Biomedical Sciences, Faculty of Medicine, University of Montreal, Montreal, QC, Canada;7. Centre for Studies in Family Medicine, Department of Family Medicine, Western University, London, ON, Canada;8. Canadian Centre for Activity and Aging, Western University, London, ON, Canada |
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| Abstract: | BackgroundWe examined the sensitivity of different executive function measures for detecting deficits in Parkinson's disease patients without dementia.MethodsTwenty-one non-demented PD subjects and 21 neurologically healthy controls were administered widely used clinical executive functioning measures as well as the NIH EXAMINER battery, which produces Cognitive Control, Working Memory, and Verbal Fluency scores, along with an overall Executive Composite score, using psychometrically matched scales.ResultsNo significant differences between groups were observed on widely used clinical measures. The PD patients scored lower than controls on the EXAMINER Executive Composite, Cognitive Control, and Working Memory Scores.ConclusionsThe NIH EXAMINER Executive Composite and Cognitive Control Scores are sensitive measures of executive dysfunction in non-demented PD, and may be more sensitive than several widely used measures. Results highlight the importance of careful test selection when evaluating for mild cognitive impairment in PD. |
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| Keywords: | Parkinson's disease Mild cognitive impairment Executive function Cognitive control Working memory |
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