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Decreased movement-related beta desynchronization and impaired post-movement beta rebound in amyotrophic lateral sclerosis |
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| Institution: | 1. Laboratoire de Cartographie fonctionnelle du Cerveau, UNI–ULB Neuroscience Institute, Université libre de Bruxelles (ULB), B-1070 Brussels, Belgium;2. Brain Research Unit, Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, FI-00076 AALTO, Espoo, Finland;1. Department of Neurology and Stroke, Hertie Institute for Clinical Brain Research, Eberhard-Karls-University Tübingen, Germany;2. International Max Planck Research School, Tübingen, Germany;3. School of Psychology, University of East London (UEL), London, UK;4. Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, Madrid, Spain;5. Functional and Restorative Neurosurgery, University Hospital Tübingen, Eberhard-Karls-University Tübingen, Germany;1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China;2. Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China;3. Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China;4. Department of Psychoradiology, Chengdu Mental Health Center, Chengdu 610031, China;5. Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China;1. Department of Neurology, University Medical Centre, Zalo?ka cesta 2, 1000 Ljubljana, Slovenia;2. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, 33 Queen Square, London WC1N 3BG, United Kingdom;3. Department of Psychology, Faculty of Arts, A?ker?eva 2, 1000 Ljubljana, Slovenia |
| Abstract: | ObjectiveThis study explored event-related desynchronization (ERD) and synchronization (ERS) in amyotrophic lateral sclerosis (ALS) to quantify cortical sensorimotor processes during volitional movements. We furthermore compared ERD/ERS measures with clinical scores and movement-related cortical potential (MRCP) amplitudes.MethodsElectroencephalograms were recorded while 21 ALS patients and 19 controls performed two self-paced motor tasks: sniffing and right index finger flexion. Based on Wavelet analysis the alpha and beta frequency bands were selected for subsequent evaluation.ResultsPatients generated significantly smaller resting alpha spectral power density (SPD) and smaller beta ERD compared to controls. Additionally patients exhibited merely unilateral post-movement ERS (beta rebound) whereas this phenomenon was bilateral in controls. ERD/ERS amplitudes did not correlate with corresponding MRCPs for either patients or controls.ConclusionsThe smaller resting alpha SPD and beta ERD and asymmetrical appearance of beta ERS in patients compared to controls could be the result of pyramidal cell degeneration and/or corpus callosum involvement in ALS.SignificanceThese results support the notion of reduced movement preparation in ALS involving also areas outside the motor cortex. Furthermore post-movement cortical inhibition seems to be impaired in ALS. ERD/ERS and MRCP are found to be independent measures of cortical motor functions in ALS. |
| Keywords: | Amyotrophic lateral sclerosis Electroencephalography Event-related desynchronization and synchronization Alpha and beta rhythm Voluntary movement Sniffing |
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