| PTEN?VEGF?FLT1基因在髓系白血病中的表达及其相关性研究 |
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| 引用本文： | 成志勇,牛志云,李〓琳,魏占惠,魏玉涛,董作仁,潘〓崚.PTEN?VEGF?FLT1基因在髓系白血病中的表达及其相关性研究[J].南京医科大学学报,2010(2):234. |
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| 作者姓名： | 成志勇 牛志云 李〓琳 魏占惠 魏玉涛 董作仁 潘〓崚 |
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| 作者单位： | 保定市第一医院血液内科;河北医科大学第二医院血液内科; |
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| 基金项目： | 河北省自然基金资助项目(C200500745) |
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| 摘 要： | 目的:探讨肿瘤抑制基因PTEN及血管内皮生长因子(VEGF)及其受体FLT1(VEGFR1)在白血病中的表达及其相关性。方法:应用实时荧光定量PCR(FQ-PCR)检测50例初治急性髓系白血病(AML),10例缓解期AML,10例慢性粒细胞白血病慢性期(CML-CP)、10例CML急变期(CML-BC)患者和10例正常人骨髓单个核细胞(MMNCs)中PTEN、VEGF、FLT1 mRNA的表达。结果:初治AML患者PTEN mRNA表达水平明显低于缓解组AML和正常对照组,CML-BC患者PTEN mRNA表达水平低于CML-CP患者,在AML初治白血病中PTEN mRNA与VEGF和FLT1 mRNA表达负相关,PTEN低表达、VEGF和FLT1高表达与AML缓解率及髓外浸润相关。结论:髓系白血病患者中低表达PTEN基因,高表达VEGF及FLT1基因,并与白血病预后不良及髓外浸润密切相关,三者相互作用共同参与了白血病的发病。
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| 关 键 词： | PTEN基因 血管内皮细胞生长因子 血管内皮细胞生长因子受体1 髓系白血病 |
The correlation and significance of mRNA expression of PTEN,VEGF,FLT1 in myeloid leukemia |
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| CHENG Zhi-yong,NIU Zhi-yun,Li Lin,WEI Zhan-hui,WEI Yu-tao,DONG Zuo-ren and PAN Ling.The correlation and significance of mRNA expression of PTEN,VEGF,FLT1 in myeloid leukemia[J].Acta Universitatis Medicinalis Nanjing,2010(2):234. |
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| Authors: | CHENG Zhi-yong NIU Zhi-yun Li Lin WEI Zhan-hui WEI Yu-tao DONG Zuo-ren and PAN Ling |
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| Institution: | Department of Hematology/a>;the First Hospital of Baoding/a>;Baoding 071000/a>;1Department of Hematology/a>;the Sec- ond Hospital of Hebei Medical University/a>;Shijiazhuang 050000/a>;China |
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| Abstract: | Objective:To investigate the clinical significance and relationship of tumor-suppressing gene PTEN and VEGF,FLT1 (VEGFR1) mRNA in myleod leukemia cells. Methods:The mRNA expression of PTEN and VEGF in marrow mononuclear cells (MMSCs) from 50 acute myeloid leukemia (AML) patients,10 AML patients in complete remission (CR),10 chronic myelogenous leukemia (CML) patients in chronic phase (CML-CP),10 CML patients in blast crises (CML-BC) and 10 persons as normal controls were detected by real-time fluorescent re... |
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| Keywords: | PTEN gene VEGF FLT1 myeloid leukemia |
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