| 西宁地区幽门螺旋杆菌感染与非感染溃疡病患者血清6种细胞因子的对比观察 |
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| 引用本文： | 于梅花,伍伟明,王红波,杨永耿.西宁地区幽门螺旋杆菌感染与非感染溃疡病患者血清6种细胞因子的对比观察[J].高原医学杂志,2008,18(3):11-12. |
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| 作者姓名： | 于梅花 伍伟明 王红波 杨永耿 |
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| 作者单位： | 1. 青海省人民医院核医学科,810007
2. 青海省人民医院消化科,810007 |
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| 摘 要： | 目的：了解西宁地区幽门螺杆菌（HP）感染与非感染溃疡病患者血清IL-1β、1L-2、IL-4、IL-6、IL-8、TNF—α的变化。方法：用放射免疫法测定30例HP感染与25例HP非感染溃疡病患者血清6种白介素水平含量。结果：HP感染者血清IL-4含量显著低于非HP感染者（P〈0．01），其余五种细胞因子均无显著性变化（P〉0．05）。结论：西宁地区HP感染者IL-4明显降低，这可能是溃疡病发病率高的主要机制。
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| 关 键 词： | 西宁地区 HP 溃疡病 细胞因子 |
Comparison of Six Serum Cytokines Between HP Infected and Non-HP Infected Patients with Ulcers in Xining Area |
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| Yu Meihua,Wu Weiming,Wang Hongbo,Yang Yonggeng.Comparison of Six Serum Cytokines Between HP Infected and Non-HP Infected Patients with Ulcers in Xining Area[J].Journal of High Altitude Medicine,2008,18(3):11-12. |
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| Authors: | Yu Meihua Wu Weiming Wang Hongbo Yang Yonggeng |
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| Institution: | Yu Meihua, Wu Weiming, Wang Hongbo, Yang Yonggeng ( Qinghai Provincial People＇s Hospital 810007) |
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| Abstract: | Objective：To observe the changes on serum level of IL-1β, IL-2, IL-4, IL-6, IL-8, TNF-α in helicobacter pylori （HP）infected and non-HP infected patients with ulcers in Xining area. Methods. The serum level of IL-1β, IL-2, IL-4, IL-6, IL-8, TNF-α were measured by radioimmu- noassay in HP infected patients （n=30） and no-HP infected patients （n=25）. Results：The serum level of IL-4 was significantly lower in HP infected patients only than that in non-HP infected patients （P〈0. 01）, there was no difference in other five indices （P〉0. 05）. Conclusions.. The level of IL-4 is lower in HP infected patients. This could be a important role of occurrence of stomach ulcer in Xining. |
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| Keywords: | HP |
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