|
|||||
|
|
| Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy： A prospective randomized, multicenter study | |
| 作者姓名： | Lee SH Chung IK Kim SJ Kim JO Ko BM Kim WH Kim HS Park DI Kim HJ Byeon JS Yang SK Jang BI Jung SA Jeen YT Choi JH Choi H Han DS Song JS |
| 作者单位： | Department of Internal Medicine University of Soonchunhyang at Cheonan，Cheonan & Seoul & Bucheon，Republic of Korea，Department of Internal Medicine，University of Soonchunhyang at Cheonan，Cheonan & Seoul & Bucheon，Republic of Korea，Department of Internal Medicine，University of Soonchunhyang at Cheonan，Cheonan & Seoul & Bucheon，Republic of Korea，Department of Internal Medicine，University of Soonchunhyang at Cheonan，Cheonan & Seoul & Bucheon，Republic of Korea，Department of Internal Medicine，University of Soonchunhyang at Cheonan，Cheonan & Seoul & Bucheon，Republic of Korea，Department of Internal Medicine，University of Yonsei at Seoul，Seoul & Wonju，Republic of Korea，Department of Internal Medicine，University of Yonsei at Seoul，Seoul & Wonju，Republic of Korea，Department of Internal Medicine，University of Sungkyunkwan at Seoul，Seoul，Republic of Korea，Department of Internal Medicine，University of Kyunghee at Seoul，Seoul，Republic of Korea，Department of Internal Medicine，University of Ulsan at Seoul，Seoul，Republic of Korea，Department of Internal Medicine，University of Ulsan at Seoul，Seoul，Republic of Korea，Department of Internal Medicine，University of Youngnam at Taegu，Taegu，Republic of Korea，Department of Internal Medicine，University of Ewha at Seoul，Seoul，Republic of Korea，Department of Internal Medicine，University of Korea at Seoul，Seoul & Ansan，Republic of Korea，Department of Internal Medicine，University of Korea at Seoul，Seoul & Ansan，Republic of Korea，Department of Internal Medicine，University of Catholic at Bucheon，Bucheon，Republic of Korea，Department of Internal Medicine，University of Hanyang at Kuri，Kuri，Republic of Korea，Department of Preventive Medicine，University of Kwandong，Kangneung，Republic of Korea |
| 基金项目： | a grant from the Korean Association for the Study of Intestinal Diseases |
| 摘 要： | AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. METHODS:A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) wererandomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method,and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. RESULTS:A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall,bleeding complications occurred in 7.6% (37/486) of the patients,including 4.9% (12/244) in the epinephrine group,and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients,respectively,including 4.5% (11/244),0.4% (1/244) in the epinephrine group,and 8.7% (21/242),1.7% (4/242) in the saline group. No significant differences in the rates of overall,early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. CONCLUSION:The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB. |
| 关 键 词： | 肾上腺素 常规息肉切除术 大肠息肉 出血性 |
| 收稿时间： | 2007 Mar 22 |
Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy: a prospective randomized, multicenter study |
|
| Lee SH,Chung IK,Kim SJ,Kim JO,Ko BM,Kim WH,Kim HS,Park DI,Kim HJ,Byeon JS,Yang SK,Jang BI,Jung SA,Jeen YT,Choi JH,Choi H,Han DS,Song JS.Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy: a prospective randomized, multicenter study[J].World Journal of Gastroenterology,2007,13(21):2973-2977. | |
| Authors: | Lee Suck-Ho Chung Il-Kwun Kim Sun-Joo Kim Jin-Oh Ko Bong-Min Kim Won Ho Kim Hyun-Soo Park Dong-Il Kim Hyo-Jong Byeon Jeong-Sik Yang Suk-Kyun Jang Byeong Ik Jung Sung-Ae Jeen Yoon-Tae Choi Jai-Hyun Choi Hwang Han Dong-Soo Song Jae-Suk |
| Institution: | 1. Department of Internal Medicine, University of Soonchunhyang at Cheonan, Cheonan & Seoul & Bucheon,Republic of Korea 2. Department of Internal Medicine,University of Yonsei at Seoul, Seoul & Wonju, Republic of Korea 3. Department of Internal Medicine, University of Sungkyunkwan at Seoul, Seoul, Republic of Korea 4. Department of Internal Medicine, University of Kyunghee at Seoul, Seoul, Republic of Korea 5. Department of Internal Medicine, University of Ulsan at Seoul, Seoul, Republic of Korea 6. Department of Internal Medicine, University of Youngnam at Taegu, Taegu, Republic of Korea 7. Department of Internal Medicine, University of Ewha at Seoul, Seoul, Republic of Korea 8. Department of Internal Medicine, University of Korea at Seoul, Seoul & Ansan, Republic of Korea 9. Department of Internal Medicine, University of Catholic at Bucheon, Bucheon, Republic of Korea 10. Department of Internal Medicine, University of Hanyang at Kuri, Kuri, Republic of Korea 11. Department of Preventive Medicine, University of Kwandong, Kangneung, Republic of Korea |
| Abstract: | AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. METHODS:A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) wererandomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method,and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. RESULTS:A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall,bleeding complications occurred in 7.6% (37/486) of the patients,including 4.9% (12/244) in the epinephrine group,and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients,respectively,including 4.5% (11/244),0.4% (1/244) in the epinephrine group,and 8.7% (21/242),1.7% (4/242) in the saline group. No significant differences in the rates of overall,early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. CONCLUSION:The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB. |
| Keywords: | Colonoscopic polypectomy Bleeding submucosal injection Saline Epinephrine |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |