Dynamics of development of the metabolic and compositional alterations of depot fat in hypothalamic obese rats |
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| Authors: | S E Starr J D Crawford H A Haessler |
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| Affiliation: | 1. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.;2. the Children''s Service, Massachusetts General Hospital, Boston, Massachusetts, USA.;3. the Life Sciences Division of the Scientific Engineering Institute, Waltham, Massachusetts, USA.;1. State Key Laboratory of Southwestern Chinese Medicine Resources, Ministry of Education, Chengdu 611137, China;2. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;3. Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China;4. College of Animal Science and Technology, Southwest University, Chongqing 400715, China;1. Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China;2. College of Food Science and Technology of Huazhong Agricultural University, Wuhan 430070, China;3. College of Food and Biotechnology, Wuhan Institute of Design and Science, Wuhan 430205, China;4. College of Food Science and Engineering, Hainan University, Haikou 570228, China |
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| Abstract: | ![]()
In rats destined to become obese as a result of lesion placement in the ventromedial hypothalamus, study of serial biopsy specimens of epidymal fat showed that impairment of epinephrine stimulated free fatty acid (FFA) release to incubation medium occurred more promptly than the alteration in distribution of total tissue (largely glyceride) fatty acids. Both were nearly fully developed by the sixth postoperative day, well before gross obesity was manifest. When the alteration of fatty acid distribution in tissue reached full development its extent became closely correlated with the reduction in hormone stimulated FFA release. The findings support the concept that in rats with hypothalamic lesions predisposing to obesity there is an early impairment of the hormone sensitive lipase system of adipose tissue, and that this defect underlies the alteration in the pattern of distribution of fatty acids within the tissue. |
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