Bcl11bmutations identified in murine lymphomas increase the proliferation rate of hematopoietic progenitor cells |
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| Authors: | Anneli Karlsson Amanda Nordigården Jan-Ingvar Jönsson Peter Söderkvist |
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| Affiliation: | 1.Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences,Link?ping University,Link?ping,Sweden |
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| Abstract: | Background The telomeric region of mouse chromosome 12 has previously shown frequent allelic loss in murine lymphoma. The Bcl11b gene has been identified and suggested as a candidate tumor suppressor gene within this region. In this study, we aimed to elucidate whether Bcl11b is mutated in lymphomas with allelic loss, and whether the mutations we detected conferred any effect on cell proliferation and apoptosis. |
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