| 结核分枝杆菌新疆临床分离株耐药情况调查 |
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| 引用本文： | 曹红艳,吴长东,米利古,刘佩芝,陈伟,王远志,李永祥,袁俐. 结核分枝杆菌新疆临床分离株耐药情况调查[J]. 中国病原生物学杂志, 2010, 0(4) |
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| 作者姓名： | 曹红艳 吴长东 米利古 刘佩芝 陈伟 王远志 李永祥 袁俐 |
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| 作者单位： | 新疆石河子大学医学院;新疆石河子大学第一附属医院感染科; |
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| 基金项目： | 国家自然科学基金资助项目(No.30960356) |
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| 摘 要： | 目的分析新疆部分地区结核分枝杆菌(MTB)临床分离株对抗结核药物的耐药情况,探讨本地区耐药结核病的发生率及特点。方法收集2008年11月～2009年10月新疆喀什、和田、皮山等南疆地区确诊的结核病患者痰液标本,进行MTB的分离培养及菌种初步鉴定,并应用比例法对分离菌株进行耐药性检测,与本课题组所做北疆地区耐药情况进行比对。结果共分离到102株分枝杆菌,88株(86.3%)属于结核分枝杆菌复合群,7株(6.9%)属于牛分枝杆菌,7株(6.9%)属于非结核分枝杆菌。88株结核分枝杆菌中对1种以上抗结核药物具有耐药性的有20株,总耐药率为22.7%(20/88),MDR-TB为6.8%(6/88)。新疆南疆地区4种一线抗结药物的耐药率:H15.9%、R8.0%、S12.5%、E3.4%,明显低于新疆北疆地区抗结药物的耐药率:H53.3%、R28.5%、S48.4%、E46.8%。结论新疆南疆地区结核总耐药率有所下降,耐多药率有上升趋势,在结核病防治工作中应给予高度重视;新疆南、北疆地区耐药情况不同,北疆耐药率明显高于南疆地区。
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| 关 键 词： | 分枝杆菌 结核 耐药性 耐多药结核分枝杆菌 |
Investigation of the drug-resistance of Mycobacterium tuberculosis clinical isolates from Xinjiang |
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| CAO Hong-yan,WU Chang-dong,MI Li-gu,LIU Pei-zhi,CHEN Wei,WANG Yuan-zhi,LI Yong-xiang,YUAN Li. Investigation of the drug-resistance of Mycobacterium tuberculosis clinical isolates from Xinjiang[J]. Journal of Pathogen Biology, 2010, 0(4) |
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| Authors: | CAO Hong-yan WU Chang-dong MI Li-gu LIU Pei-zhi CHEN Wei WANG Yuan-zhi LI Yong-xiang YUAN Li |
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| Affiliation: | CAO Hong-yan1,WU Chang-dong1,MI Li-gu1,LIU Pei-zhi2,CHEN Wei1,WANG Yuan-zhi1,LI Yong-xiang1,YUAN Li1(1.College of Medicine,Shihezi University,Shihezi 832002,Xinjiang,China,2.Department of Infectious Disease,The First Affiliated Hospital of Shihezi University,Shihezi 832008,China) |
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| Abstract: | Objective To analyze anti-TB drug resistance in clinical isolates of Mycobacterium tuberculosis(MTB)from several areas of Xinjiang and ascertain the rate of drug resistance and characteristics of MTB in these regions.Methods Sputum samples from patients with TB were collected from Kashi,Hetian,Pishan,and other regions of southern Xinjiang from Nov.2008 to Oct.2009.The separation,culture,and preliminary identification of MTB were done.Anti-tuberculosis drugs were used to detect the drug resistance of MTB via... |
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| Keywords: | Mycobacterium tuberculosis drug resistance multi-drug resistant Mycobacterium tuberculosis |
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