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Phase I study of glasdegib (PF‐04449913), an oral smoothened inhibitor,in Japanese patients with select hematologic malignancies
Authors:Yosuke Minami  Hironobu Minami  Toshihiro Miyamoto  Goichi Yoshimoto  Yukio Kobayashi  Wataru Munakata  Yasushi Onishi  Masahiro Kobayashi  Geoffrey Chan  Adrian Woolfson  Chiho Ono  Mohammed Naveed Shaik  Yosuke Fujii  Xianxian Zheng  Tomoki Naoe
Affiliation:1. National Cancer Center Hospital East, Kashiwa, Chiba, Japan;2. Kobe University Hospital, Kobe, Hyogo, Japan;3. Kyushu University Hospital, Fukuoka, Fukuoka, Japan;4. National Cancer Center Hospital, Chuo‐ku, Tokyo, Japan;5. Tohoku University Hospital, Sendai, Miyagi, Japan;6. Pfizer Inc, Collegeville, Pennsylvania, USA;7. Pfizer Inc, New York City, New York, USA;8. Pfizer Japan, Shibuya‐ku, Tokyo, Japan;9. Pfizer Inc, San Diego, California, USA;10. National Hospital Organization Nagoya Medical Center, Nagoya, Aichi, Japan
Abstract:
Keywords:Glasdegib  hedgehog signaling pathway  hematologic malignancies  Japanese  smoothened
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