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| 二氧化硫对自发性高血压大鼠主动脉平滑肌细胞内质网应激的影响 | |
| 引用本文： | 朱露璐,赵霞,唐朝枢,杜军保,金红芳. 二氧化硫对自发性高血压大鼠主动脉平滑肌细胞内质网应激的影响[J]. 首都医科大学学报, 2010, 31(2): 183-186 |
| 作者姓名： | 朱露璐 赵霞 唐朝枢 杜军保 金红芳 |
| 作者单位： | 朱露璐,赵霞,金红芳(北京大学第一医院儿科);唐朝枢(北京大学医学部生理与病理生理教研室;北京大学教育部分子心血管重点实验室);杜军保(北京大学第一医院儿科;北京大学教育部分子心血管重点实验室) |
| 基金项目： | 国家自然科学基金，教育部博士点基金，教育部科学技术研究重大项目，国家重大基础研究发展计划项目，北京市自然科学基金 |
| 摘 要： | 目的探讨二氧化硫(sulfur dioxide,SO2)对自发性高血压大鼠(spontaneously hypertensive rat,SHR)主动脉平滑肌细胞内质网应激的调节作用。方法4周龄正常血压WKY(wistar-kyoto rat)大鼠7只作为WKY对照组。4周龄SHR大鼠12只分为SHR(spontaneously hypertensive rat)对照组及SHR+SO2供体(Na2SO3/NaHSO3)组,每组6只。5周后检测大鼠血压,采用高效液相色谱(HPLC)法测定血浆SO2水平,采用免疫组织化学方法检测主动脉平滑肌细胞GRP78和caspase-12的蛋白表达。结果9周时SHR对照组血压明显高于WKY对照组,血浆SO2水平显著低于WKY对照组,主动脉平滑肌细胞GRP78和caspase-12蛋白表达显著增高。与SHR对照组比较,SHR+SO2供体组大鼠血压明显降低,血浆SO2含量升高,主动脉平滑肌细胞GRP78和caspase-12蛋白表达降低。结论SO2可能抑制高血压大鼠主动脉血管平滑肌细胞内质网应激反应的激活。 |
| 关 键 词： | 二氧化硫 高血压 主动脉 内质网应激 |
Impact of Sulfur Dioxide on the Endoplasmic Reticulum Stress of Aortic Smooth Muscle Cells in the Spontaneously Hypertensive Rats |
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| ZHU Lu-lu,ZHAO Xia,TANG Chao-shu,,DU Jun-bao,JIN Hong-fang. Impact of Sulfur Dioxide on the Endoplasmic Reticulum Stress of Aortic Smooth Muscle Cells in the Spontaneously Hypertensive Rats[J]. Journal of Capital Medical University, 2010, 31(2): 183-186 | |
| Authors: | ZHU Lu-lu ZHAO Xia TANG Chao-shu DU Jun-bao JIN Hong-fang |
| Affiliation: | ZHU Lu-lu1,ZHAO Xia1,TANG Chao-shu2,3,DU Jun-bao1,JIN Hong-fang1(1.Department of Pediatrics,Peking University First Hospital,2.Department of Physiology , Pathophysiology,Peking University Health Science Center,3.Key Laboratory of Molecular Cardiovascular Diseases,Ministry of Education) |
| Abstract: | Objective To explore the effect of sulfur dioxide(SO2) on the endoplasmic reticulum stress(ERS) in the aortic smooth muscle cells of spontaneously hypertensive rat(SHR).Methods Seven male WKY rats were used as WKY control group.Twelve male SHRs at the age of 4 weeks were randomly divided into SHR control group and SHR+SO2 donor(Na2SO3/NaHSO3) group,respectively.Five weeks later,the blood pressure was determined.SO2 content in the plasma was detected by reverse-phase high performance liquid chromatography wi... |
| Keywords: | sulfur dioxide hypertension aortic endoplasmic reticulum stress |
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