轻度认知功能障碍患者的神经心理学特点初步探讨

目的 通过比较遗忘型轻度认知障碍(amnestic mild cognitive impairment,aMCI)和血管性认知障碍非痴呆型(vascular cognitive impairment-no dementia,VCFND)患者及正常老年人群在简易智能精神状态检查量表(mini mental state e...

Neuropsychological Characteristics in the Patients with Amnestic Mild Cognitive Impairment

Objective To investigate the different patterns of cognitive impairment in patients with amnestic mild cognitive impairment（amci）,vascular cognitive impairment-no dementia（VCI-ND） and normal elder people.Methods A total of 23 patients with aMCI and 27 patients with VCI-ND（CDR=0.5） and another 40 healthy elder people（CDR=0） were selected.Each individual underwent the neuropsychological tests,including mini mental state examination（MMSE）,auditory verbal learning test（AVLT）,clock drawing test（CDT）,clinical dementia rating scales（CDR） and hamilton rating scale for depression（HAMD）.The differences between the three groups were analyzed.Results The differences in age,sexes,and the education background among the three groups were not significant（P〉0.05） which meant comparability.The mean scores of MMSE,CDT,instant memory and delayed awareness in aMCI and VIC-ND group were much lower than that in the control group（P〈0.05）.The differences in all the test items except for delayed awareness between aMCI group and VCI-ND groups were not significant（P〉0.05）.However,in the recall recognition test,these three groups had significant differences： the score in patients with aMCI（6.65±4.00） was much lower than that in patients with VCI-ND（8.67±2.76;P〈0.05）,and the scores of the two groups were both lower than that in the normal aging group（12.83±1.77;P〈0.05）.Conclusions Compared with normal elder people,the cognition of aMCI and VCI-ND patients is impaired severely.The memory tests suggeste that compared with aMCI patients,VCI-ND patients may have different neuropathological changes leading to different mechanism of memory encoding and retrieval