干扰素治疗蕈样霉菌病的系统评价

目的 采用系统评价方法,评估干扰素(IFN)治疗蕈样霉菌病(MF)的疗效及安全性.方法 计算机检索截止2010年5月的Cochrane协作网系统评价方法,纳入所有比较IFN与其他方法治疗MF的随机对照试验及临床对照试验进行质量评价,采用RevMan 5.0.24软件进行Meta分析.结果 共纳入6篇符合标准的已发表文献...

Interferon Therapy for Mycosis Fungoides: A Systematic Review

Objective To evaluate the clinical efficacy and side effects of interferon（IFN） in the treatment of mycosis fungoides（MF） with the method of systematic review.Methods According to the Cochrane reviewer＇s handbook,all the clinical controlled trials involving mycosis fungoides being treated with interferon were retrieved.The Cochrane Collaboration＇s software RevMan 5.0.24 was used for meta-analysis.Results Only six papers including 142 patients met the inclusion criteria.Meta-analyses indicated the results as follows： IFN-α monotherapy was more effective than placebo [OR=69.36,95% CI（3.71-1 296.64）] and a traditional Chinese medicine（Di-jing-dan） [OR=35.53,95% CI（1.78-710.56）],but no significant difference was found between INF-α and thymic peptide [OR=15.11,95% CI（0.71-322.61）],and between IFN-α monotherapy and IFN-α combined with etretinate therapy [OR=3.10,95% CI（0.79-12.12）];and there was no significant difference between the efficacy of IFN-γ combined narrowband ultraviolet B（NB-UVB） therapy and that of single NB-UVB therapy [OR=15.00,95% CI（0.46-485.32）];Influenza-like side effects occurred to 90% of all the patients,which were usually slight and easy to release.Conclusion Although there are some mild side effects,interferon is safe to treat MF.