| 老年高血压合并左室肥厚患者交感神经活性的临床研究 |
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| 引用本文： | 陈积雄,黄晓燕,王萍,林文婷,符秀虹,何阳利,曾敏. 老年高血压合并左室肥厚患者交感神经活性的临床研究[J]. 心血管康复医学杂志, 2019, 0(3): 301-306 |
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| 作者姓名： | 陈积雄 黄晓燕 王萍 林文婷 符秀虹 何阳利 曾敏 |
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| 作者单位： | 海南省人民医院保健中心三区 |
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| 摘 要： | 目的:研究老年高血压(EH)合并左室肥厚(LVH)患者的交感神经活性。方法:选择2015年6月-2017年6月我院老年EH患者248例,按血压水平,患者被分为高血压1级组(78例)、2级组(89例)和3级组(81例)。其中按有无LVH,患者被分成无LVH组(122例)、合并LVH组(126例)。LVH患者按血压水平被分为:高血压1级组(28例)、2级组(41例)、3级组(57例)。选择130名健康体检老年人作为正常老年组。测定比较各组血浆去甲肾上腺素(NE)和肾上腺素(E)浓度,同时测定24h动态心电图。结果:与正常老年组相比,合并LVH组和无LVH组NE[(238.33±18.04)ng/L比(312.90±23.20)ng/L,(279.28±20.85)ng/L]、E[(262.86±24.56)ng/L比(366.57±25.53)ng/L,(301.20±23.80)ng/L]浓度明显升高(P均=0.001),且随着血压分级的升高,血浆NE和E浓度逐渐显著升高,P均=0.001;合并LVH组和无LVH组的平均心率[(64.80±5.40)次/分比(69.02±4.56)次/分,(66.72±4.98)次/分]均显著升高(P=0.001,0.017);非LVH组,合并LVH组的SDNN[(122.07±7.73)ms比(109.51±8.13)ms,(99.25±7.89)ms]、SDANN[(111.72±13.33)ms比(103.52±10.41)ms,(94.78±8.75)ms]、rMSSD[(43.98±6.31)ms比(37.25±6.42)ms,(32.05±5.19)ms]、PNN50[(7.67±0.71)%比(5.41±0.67)%,(3.39±0.63)%]则显著下降,P均=0.001,且随着血压分级的升高,上述各指标均显著下降,P均=0.001。结论:老年高血压合并左室肥厚患者交感神经活性升高明显,控制交感神经活性将有助于改善预后。
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| 关 键 词： | 高血压 肥大,左心室 交感神经系统 |
Clinical study of sympathetic activity in aged hypertensive patients with left ventricular hypertrophy |
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| CHEN Ji-xiong,HUANG Xiao-yan,WANG Ping,LIN Wen-ting,FU Xiu-hong,HE Yang-li,ZENG Min. Clinical study of sympathetic activity in aged hypertensive patients with left ventricular hypertrophy[J]. Chinese Journal of Cardiovascular Rehabilitation Medicine, 2019, 0(3): 301-306 |
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| Authors: | CHEN Ji-xiong HUANG Xiao-yan WANG Ping LIN Wen-ting FU Xiu-hong HE Yang-li ZENG Min |
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| Affiliation: | (Third District of Health Care Center, Hainan Provincial People's Hospital, Haikou, Hainan, 570311, China.) |
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| Abstract: | CHEN Ji-xiong;HUANG Xiao-yan;WANG Ping;LIN Wen-ting;FU Xiu-hong;HE Yang-li;ZENG Min(Third District of Health Care Center, Hainan Provincial People's Hospital, Haikou, Hainan, 570311, China.) |
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| Keywords: | Hypertension Hypertrophy, left ventricular Sympathetic nervous system |
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