生物制剂在炎性关节炎中的临床应用进展*

炎性关节炎包括类风湿关节炎、强直性脊柱炎、银屑病关节炎等,是一组慢性、进展性炎性疾病,能够导致关节疼痛和功能障碍。生物治疗包括多种类型针对不同疾病发病机制的制剂。近年来,根据不同免疫和炎症机制已经研发出了多种新型的生物治疗方法。现综合国内外的文献报道和治疗进展,对近年来热点报道的生物制剂如肿瘤坏死因子阻滞剂、IL-1受体阻滞剂、IL-6受体单克隆抗体等在炎性关节炎中的应用和治疗进展进行综述,为生物制剂在风湿病中的应用提供参考。

Clinical progression of biological agents on inflammatory arthritis

Inflammatory arthritis is comprised of rheumatoid arthritis,ankylosing spondylitis and psoriatic arthritis and so on.They are a group of chronic,progressive inflammatory condition that can lead to significant disability and joint pains.Biologic therapy includes many different categories of agents targeted to diverse mechanisms of disease.Recently,a host of novel biologic therapies have been developed to attack a wide variety of immunologic and inflammatory mechanisms.This article reviewed the treatment development of biological agents,such as tumor necrosis factor blocking agents,interleukin 1 receptor antagonist and interleukin 6 receptor monoclonal antibody on inflammatory arthritis.It provides advanced therapeutic information for rheumatic diseases.