锡类散治疗慢性宫颈炎的机理研究

目的：探讨锡类散治疗慢性宫颈炎的药效机理,研究锡类散的抗炎作用。方法：采用二甲苯致小鼠耳廓肿胀以及冰醋酸致小鼠腹腔通透性增加法致炎。结果：锡类散0.17、0.34和0.68g/kg剂量组小鼠耳肿胀度以及小鼠腹腔通透性增加与空白对照组比较均有不同程度下降,有统计学差异（P〈0.01,P〈0.001）。结论：锡类散能减轻二甲苯所致小鼠耳肿胀程度,能减轻冰醋酸致腹腔毛细血管通透性的增加,降低伊文思蓝从毛细血管向腹腔内渗出,具有抑制炎症早期毛细血管通透性增高的作用,提示：锡类散具有明显的抗炎作用。

Explore the Drug Effect Mechanism of Xilei San Treating Chronic Cervicitis

Objective: To explore the drug effect mechanism of Xilei San treatmenting chronic cervicitis, and to research anti-inflammatory actions of Xilei San. Methods: Dimethylbenzene causing mouse auricular engorgement and glacial acetic acid causing mouse abdomen permeability augment were used to inflammation. Results: Comparing with blank control group, auricular engorgement and abdomen permeability augment of all 3 mouse groups (using 0.17g/kg, 0.34g/kg and 0.68g/kg) decreases with significant different levels (P<0.01, P<0.001). Conclusions: Xilei San may reduce mouse auricular engorgement caused by dimethylbenzene and mouse abdomen permeability augment caused by glacial acetic acid, decrease evans blue effusion from capillary vessel to cavity of the abdomen, and have inhibit ability of early capillary vessel permeability augmenting by inflammation. Hint: Xilei San has markedly anti-inflammatory effects.