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| HPLC法测定石杉碱甲缓释片中石杉碱甲的含量 | |
| 引用本文： | 钟开位,张潮林. HPLC法测定石杉碱甲缓释片中石杉碱甲的含量[J]. 广东药学院学报, 2010, 26(1): 70-72. DOI: 10.3969/j.issn.1006-8783.2010.01.021 |
| 作者姓名： | 钟开位 张潮林 |
| 作者单位： | 东莞市广济医院,药剂科,广东,东莞,523690;深圳万和制药有限公司,广东,深圳518057 |
| 摘 要： | 目的测定石杉碱甲亲水凝胶骨架缓释片中石杉碱甲的含量。方法采用高效液相色谱法,Kromasil C18柱,甲醇-0.02%三乙醇胺溶液（体积比60∶40）为流动相,检测波长为309 nm,流速为1.0mL·min^-1,柱温为30℃,进样量20μL。结果石杉碱甲在1.041-52.05μg·mL^-1范围内有良好的线性关系,r=0.999 6。平均回收率为99.37%,RSD=0.40%。结论本方法简便、准确、专属性强,可用于该制剂的质量控制。 |
| 关 键 词： | 石杉碱甲 亲水凝胶骨架缓释片 高效液相色谱法 含量测定 |
Determination of the content of huperzine A in huperzine A hydrophilic matrix sustained-release tablets by HPLC |
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| ZHONG Kai-wei,ZHANG Chao-lin. Determination of the content of huperzine A in huperzine A hydrophilic matrix sustained-release tablets by HPLC[J]. Academic Journal of Guangdong College of Pharmacy, 2010, 26(1): 70-72. DOI: 10.3969/j.issn.1006-8783.2010.01.021 | |
| Authors: | ZHONG Kai-wei ZHANG Chao-lin |
| Affiliation: | ZHONG Kai-wei1,ZHANG Chao-lin2 (1.Pharmaceutical Preparation Section of Guangji Hospital of Dongguan City,Dongguan,Guangdong 523690,China,2.Shenzhen Wanhe Pharmaceutical Co.,Ltd.Shenzhen,Guangdong 518057,China) |
| Abstract: | Objective To establish a method for the determination of huperzine A in huperzine A hydrophilic matrix sustained-release tablets.Methods HPLC was performed on a C18 column using mathanol-0.02%triethanolamine（60∶40） as the mobile phase at a flow rate of 1 mL·min^-1.The detection wavelength was at 309nm.The column temperature was 30 ℃ and the sample size was 20 μL.Results The linear range of huperzine A was 1.041 ～52.05 μg·mL-1（r=0.999 6）,the average recovery was 99.37%（RSD=0.40%）.Conclusions The method is simple,accurate,special and can be used for the quality control of huperzine A hydrophilic matrix sustained-release tablets. |
| Keywords: | huperzine A hydrophilic matrix sustained-release tablets HPLC content determination |
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