Development and Evaluation of an Epstein-Barr Virus (EBV) Immunoglobulin M Enzyme-Linked Immunosorbent Assay Based on the 18-Kilodalton Matrix Protein for Diagnosis of Primary EBV Infection |
| |
| Authors: | K. H. Chan R. X. Luo H. L. Chen M. H. Ng W. H. Seto J. S. M. Peiris |
| |
| Affiliation: | Department of Microbiology, Queen Mary Hospital,1. and The University of Hong Kong,2. Hong Kong, and Department of Pharmacology and Molecular Science, School of Medicine, John Hopkins University, Baltimore, Maryland3. |
| |
| Abstract: | ![]()
A new immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA) based on the recombinant Epstein-Barr virus (EBV) matrix protein was developed. Compared to indirect immunofluorescence for the detection of IgM antibody to the EBV capsid antigen on clinical specimens, the sensitivity and specificity of the new IgM ELISA were 96 and 96%, respectively. |
| |
| Keywords: | |
|
|
