吡咯列酮对家兔血脂水平的影响及安全性评估

目的:探讨吡咯列酮对家兔血脂水平的影响及安全性。方法:将36只新西兰白兔随机分为正常对照组、高胆固醇饮食组、高胆固醇饮食加吡咯列酮组,喂养8周后处死,取兔血清测定血脂、肝功及肾功。结果:高胆固醇饮食组及高胆固醇饮食加吡咯列酮组TC、TG、LDL-C均高于正常对照组,HDL-C水平均低于正常对照组(P<0.05);高胆固醇饮食加吡咯列酮组TG水平低于高胆固醇饮食组,HDL-C高于高胆固醇饮食组(P<0.05)。三组间血清谷丙转氨酶、肌酐水平比较均无显著性差异(P<0.05)。结论:吡格列酮可降低高脂饮食兔血清TG水平,升高高脂饮食兔血清HDL-C水平,对肝肾功能无影响。

Effection on lipid and drug safety of pioglitazone in rabbits

Objective:To investigate the effection on lipid and drug safety of pioglitazone in rabbits.Methods:36 healthy WHHL rabbits were randomly divided into 3 groups:normal control group,high-cholesterol diet group,high-cholesterol diet with pioglitazone group.All animals were feeding for 8 weeks and sacrificed.At the end of the treatment,took rabbits blood to measure lipids,hepatic function and renal function respectively.Results:Serum TC,TG,LDL-C in high-cholesterol diet group,high-cholesterol diet with pioglitazone group were higher than in normal control group,HDL-C was lower than normal control group(P<0.05).In high-cholesterol diet with pioglitazone group,serum TG was lower comparision to high-cholesterol diet group,HDL-C was higher(P<0.05).Among the 3 groups,there is no significant difference about serum ALT and Cr(P0.05).Conclusion:Preventive taking pioglitazone can reduce the elevated TG level and increaseHDL-C level in high-fat diet rabbits,there is no impact on hepatic and renal function.