青岛地区498株结核分支杆菌耐药情况分析

①目的探讨青岛地区结核菌株耐药情况，为临床治疗提供参考依据。②方法采用ＢＡＣＴＥＣ－４６０ＴＢ法对结核分支杆菌进行分离培养与耐药测定。③结果痰结核分支杆菌阳性病人４９８例，其中初治耐药率３６．９％，其中４种药全耐药占３．９％，耐药顺位：异烟肼（Ｈ）、链霉素（Ｓ）、利福平（Ｒ）、乙胺丁醇（Ｅ），分别为３０．３％，１６．９％，１０．９％，７．４％；复治耐药率８４．６％，４药全部耐药者占１２．６％，耐药顺位为Ｈ（８１．８％），Ｓ（４８．６％），Ｒ（６４．０％），Ｅ（２６．６％）；耐ＨＲ，ＳＨＲ，ＨＲＥ初治者为９．９％，７．４％，４．２％，复治者为６１．７％，３９．７％，２１．０％．④结论我市结核病耐药情况严重，对结核病的临床治疗和管理应给予足够的重视。

ANALYSIS OF DRUG RESISTANCE OF 498 TUBERCLE BACILLI STRAIN IN QINGDAO AREA

Objective To explore drug resistance of Mycobacterium Tuberculosis in Qingdao area and provide reference for clinical treatment. Methods Mycobacterium was cultured with BACTEC 460 TB and drug resistance was measured. Results In all of the 498 cases with tuberculosis, the rate of initial resistance was 36.9%. The rate of resistance to all the four drugs was 3.9%, the sequence of drug resistance was:hidrasonil(H) 30.3%, streptomycin(S) 16.9%, rifampin(R) 10.9% and ethmbutol(E) 7.4%. Acquired resistance rate was 84.6%, the rate of resistance to all the 4 drugs was 12.6, the sequence of drug resistance was H 81.8%, S 48.6%, R 64.0% and E 26.6%. The initial rate of resistance to HR, SHR, HRE were 9.9%, 7.4% and 4.2% respectively. The acquired rate of resistance to HR, SHR, HRE were 61.7%, 39.7% and 21.0% respectively. Conclusion The drug resistance of tuberculosis mycobacterium in Qingdao area was serious. The management and clinical treatment for tuberculosis patient must be emphasized.