硫普罗宁防治大剂量甲氨蝶呤致儿童肝损害临床观察

目的:观察硫普罗宁(THIOLA)改善甲氨蝶呤致儿童肝损害的疗效。方法:采用硫普罗宁注射剂防治甲氨蝶呤所引起的肝损害103例,并在同样条件下用美能(β-甘草酸复方制剂StrongerNeo-MinophagenC)防治肝损害42例作为对照,对比肝功能各项实验室检测指标。结果:治疗组,对照组对化疗中造成的肝损害都具有明显的疗效,33%未表现明显肝损害,67%表现明显肝功能异常,继续使用保肝药后肝功能恢复正常。治疗组与对照组效果无显著差异(P>0.05)。结论:硫普罗宁在急性淋巴细胞白血病患儿化疗时同步应用,可有效地保护肝细胞,明显改善肝功能,其效果与美能相同。

Observation on the efficacy of tiopronin in children with liver damage caused by high dose methotrexate

Objective: To observe the efficacy of tiopronin in children with liver damage caused by high dose methotrexate. Methods:In 103 cases,tiopronin injection was for the management of chemotherapy-induced liver damage. And Stronger Neo-Minophagen C was used in 42 cases as control. Results: In tiopronin group, 33 percent of cases maintained normal liver function, and the remaining developed liver damage, which would resolve if tiopronin administration continued. As for the efficacy, no statistical difference was observed between treatment group and control group(P> 0.05). Conclusion: Tiopronin can effectively prevent liver cells and improve liver function, and can be combined with methrexate in treatment of children with acute lymphoblastic leukemia.