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Mechanisms controlling expression of the RAG locus during lymphocyte development
Authors:Tracy C Kuo  Mark S Schlissel
Affiliation:1. Allergy Immunology and Blood and Marrow Transplant Division, University of California San Francisco Benioff Children''s Hospital, San Francisco, Calif;2. Paediatric Immunology Department, Great North Children''s Hospital, Newcastle upon Tyne, United Kingdom;1. Massachusetts General Hospital, Harvard Medical School, Boston, Mass;2. Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway;3. University of South Florida and Johns Hopkins All Children''s Hospital, Saint Petersburg, Fla;4. Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, Md;5. Division of Allergy and Immunology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah;6. Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio;7. Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;8. Faculty of Medicine, Pediatrics Department, Kuwait University, Kuwait City, Kuwait;9. Allergy and Clinical Immunology Unit, Pediatrics Department, Alsabah Hospital, Kuwait City, Kuwait;10. Department of Pathology and Laboratory Medicine, Nationwide Children''s Hospital, Columbus, Ohio;11. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn;12. Division of Pediatric Allergy/Immunology, Mayo Clinic Children''s Center Rochester, Rochester, Minn;13. Department of Pediatrics, UNIFESP-EPM, São Paulo, Brazil;14. Pediatrics/Hematology, CHOC Children''s Hospital - UC Irvine, Irvine, Calif;15. Department of Paediatric Immunology, Great Ormond Street Hospital, London, United Kingdom;p. Division of Rheumatology, Children''s Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, Calif;q. Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa;r. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;s. Department of Pediatrics, University of California San Francisco and UCSF Benioff Children''s Hospital, San Francisco, Calif;t. Sidra Medicine, Weill Cornell Medicine, and Hamad Medical Corporation, Doha, Qatar;u. Academic Department of Pediatrics (DPUO), Unit of Immune and Infectious Diseases, Childrens'' Hospital Bambino Gesù, Rome, Italy;v. Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;w. Academic Department of Pediatrics (DPUO), Research Unit in Congenital and Perinatal Infection, Children''s Hospital Bambino Gesù, Rome, Italy;x. Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, IRCCS, Ospedale Bambino Gesù, Rome, Italy;y. Department of Pediatrics, Sapienza, University of Rome, Rome, Italy;z. Immunology Division, Department of Pediatrics, Boston Children''s Hospital, Harvard Medical School, Boston, Mass;11. Department of Immunology - Histocompatibility, Specialized Center & Referral Center for Primary Immunodeficiencies - Paediatric Immunology, ”Aghia Sophia” Children''s Hospital, Athens, Greece;22. 1st Department of Pediatrics, University of Athens, Aghia Sofia Children''s Hospital, Athens, Greece;33. Division of Allergy, Immunology and Pulmonary Medicine, Duke University School of Medicine, Durham, NC;44. Division of Pediatric Blood and Marrow Transplantation, Duke University School of Medicine, Durham, NC;55. Department of Pediatrics and Adolescent Medicine, Center for Infectious Diseases Research, American University of Beirut, Beirut, Lebanon;66. Division of Pediatric Hematology and Oncology & HCST Unit, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey;77. Division of Pediatric Immunology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey;88. Salmanyia Medical Complex, Department of Pediatrics, Division of Pediatric Hematology and Oncology, Manama, Bahrain;99. Department of Immunology, Boston Children''s Hospital, Harvard Medical School, Boston, Mass;1010. Division of Hematology-Oncology, Boston Children''s Hospital, Boston, Mass;1111. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Mass;1212. Harvard Medical School, Boston, Mass;1313. Division of Allergy & Immunology, Children''s Hospital Colorado, University of Colorado School of Medicine, Aurora, Colo;1414. Department of Pediatrics, National Jewish Health, Denver, Colo;1515. Immunology Outpatient Clinic, Vienna, Austria;pp. Biomedizinische Forschungs GmbH, Vienna, Austria;qq. Sigmund Freud Private University-Medical School, Vienna, Austria;rr. Division of Immunology, Boston Children''s Hospital, Harvard Medical School, Boston, Mass;ss. Hospital Infantil Pequeno Principe, Curitiba, Brazil;tt. Immunology Department, Children''s Memorial Health Institute, Warsaw, Poland;uu. Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics and Jeffrey Modell Diagnostic and Research Center, University of California, Los Angeles, Los Angeles, Calif;vv. Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Stanford University, Stanford, Calif;ww. Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Texas Children''s Hospital, Houston, Texas;xx. Department of Bone Marrow Transplantation, Hadassah Hebrew University Hospital, Jerusalem, Israel;yy. Division of Bone Marrow Transplant, Aflac Cancer and Blood Disorders Center, Children''s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Ga;zz. Haematology Unit, Department of Pediatric Haematology-Oncology, IRCCS Istituto Giannina Gaslini, Genova, Italy;111. Department of Internal Medicine, Division of Allergy/Immunology, University of South Florida Morsani College of Medicine, Tampa, Fla;222. Department for Pediatric Hematology and Hemopoietic Stem Cell Transplantation, Central Hospital of Southern Pest- National Institute of Hematology and Infectious Diseases, Budapest, Hungary;333. Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Md;444. Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa;555. Allergy Immunology Division, Department of Pediatrics, The Children''s Hospital of Philadelphia, Philadelphia, Pa;666. Institute for Immunology, the University of Pennsylvania, Philadelphia, Pa;777. Marmara University School of Medicine, Division of Pediatric Allergy and Immunology, Istanbul, Turkey;888. Ministry of Health, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey;999. Department of Pediatrics, Section Pediatric Immunology, Infections and Stem Cell Transplantation, Leiden University Medical Center, Leiden, the Netherlands;101010. Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria;111111. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria;121212. St Anna Kinderspital and Children''s Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, Vienna, Austria;131313. Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria;141414. Department of Immunology, Pirogov Russian National Research Medical University, Russian Clinical Children''s Hospital, Moscow, Russia;151515. Paris Descartes Sorbonne Paris Cité University, Imagine Institute, Paris, France;ppp. Pediatric Hematology-Immunology and Rheumatology Unit, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France;qqq. Laboratory “Immunogenetics of Pediatric Autoimmune Diseases”, INSERM UMR1163, Université Paris Descartes Sorbonne Paris Cité, Institut Imagine, Paris, France;rrr. Laboratory “Genome Dynamics in The Immune System”, INSERM UMR1163, Université Paris Descartes Sorbonne Paris Cité, Institut Imagine, Paris, France;sss. Laboratoire d''Immunologie Clinique, d''Inflammation et d''Allergie LICIA, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco;ttt. Clinical Immunology Unit, Casablanca Children''s Hospital, Ibn Rochd Medical School, Hassan II University, Casablanca, Morocco;uuu. Division of Clinical Immunology, Departments of Pathology, Pediatrics and Medicine, University of Utah, Salt Lake City, Utah;vvv. Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, Mass;1. Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA;1. Department of Molecular Biology and Genetics and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;2. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China;1. Immunology Program and Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;2. Department of Immunobiology and the Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA;1. State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, People’s Republic of China;2. Beijing University of Chinese Medicine, Dong San Huan Road, Chao-yang District, Beijing 100029, People’s Republic of China;3. Department of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA;4. Howard Hughes Medical Institute, 295 Congress Avenue, New Haven, CT 06511, USA;5. CNRS, Centrale Marseille, I2M UMR 7373, Equipe Evolution Biologique et Modélisation, Aix-Marseille Université, 13284 Marseille, France;6. CNRS, UMR 7232, Biologie Integrative des Organismes Marins (BIOM), Observatoire Océanologique de Banyuls-sur-Mer, Banyuls-sur-Mer, Université Pierre et Marie Curie, Université Paris 6, 75005 Paris, France;7. State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People’s Republic of China
Abstract:
Keywords:
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