司帕沙星、母牛分枝杆菌菌苗联合治疗耐多药肺结核

目的观察和评价司帕沙星、母牛分枝杆菌菌苗联合治疗耐多药肺结核病的疗效。方法将126例耐多药肺结核病例随机分为治疗组（64例）和对照组（62例）。观察治疗前后痰结核菌抗酸染色转阴、痰结核菌培养转阴、胸片X线病灶吸收、空洞闭合率、治疗前后CD4^＋,CD8^＋、CD4^＋／CD8^＋及IFN-γ变化、药物的不良反应。结果治疗6月后治疗组痰结核菌抗酸染色转阴率、痰结核菌培养阴转率、病灶吸收率、空洞闭合率与对照组比较差异有统计学意义（P〈0．01）。血清CD4^＋、CD8^＋百分率、CD4^＋／CD8^＋和IFN-γ浓度治疗组治疗6个月后与治疗前比较差异有统计学意义（P〈0．01）。结论应用司帕沙星、母牛分枝杆菌菌苗及其他可供使用的结核药配伍治疗耐多药结核病，能改善耐多药结核病患者的细胞免疫功能，提高耐多药结核病患者的痰结核菌抗酸染色转阴率、病灶吸收好转率、空洞闭合率，不良反应少。

Combination therapy of sparfloxacin and mycobacterium bovis vaccine for multidrug-resistant tuberculosis

Objective To observe and evaluate clinical effects of sparfloxacin combined with mycobacterium bovis vaccine in the treatment of multidrug-resistant tuberculosis （ MDR-TB ）. Methods A total of 126 patients with MDR-TB were randomly divided into the treatment group（n=64） and the control group （n=62）. These makers were observed including the sputum conversion by acid-fast stain, the sputum culture negative conversion, lesion absorption rate, the cavity closure rate, the changes of the percentage of CD4^＋ and CD8^＋ T cells in sera, the ratio of CD4^＋/CD8^＋ lymphocyte, the serum level of IFN- γ and the adverse drug reaction before and after the treatment. Results After 6 months of treatment, there were significant differences between the treatment group and the control group in sputum negative conversion by acid-fast stain, the sputum culture negative rate, the pulmonary tuberculosis lesion absorption rate and the cavity closure rate（P 〈0.01）. The percentage of CD4^＋ and CD8^＋ T cells in sera, CD4^＋/CD8^＋ ratio and the serum level of IFN- γ （P〈0.01） were significantly different in the treatment group before the treatment and after six months of treatment （P〈0.01）. Conclusions Combination therapy of sparfloxacin and mycobacterium bovis vaccine for MDR-TB may enhance the cell immune responses and improve the sputum converstion by acid-fast stain, the sputum culture negative rate, lesion absorption rate and the cavity closure rate, with slight adverse reaction.