深圳市女性子宫颈人乳头瘤病毒感染危险因素分析

目的 探讨影响深圳市人乳头瘤病毒(HPV)感染的危险因素,为HPV感染和子宫颈癌的防治工作提供依据。方法 于2011年1月—2015年12月在深圳市对2 694名成年进行问卷调查,采用液基薄层细胞学检查(TCT)及宫颈HPV DNA检测,阴道镜检查、组织活检及病理检查,分析不同年龄组HPV感染情况,采用多因素非条件Logistic回归模型分析HPV感染的危险因素。结果 调查结果显示,HPV的感染率为17.8%（480例）,单纯高危型和单纯低危型HPV感染率分别为16.0%和1.8%。高危性HPV感染者432例,以52型、16型、53型、51型、58型为主,感染率分别为3.6%、1.9%、1.5%、1.4%、1.2%;低危型感染者48例,主要致病亚型为HPV81（0.8%）、HPV6（0.3%）和HPV11（0.3%）。单因素分析后,具有显著统计意义的变量有: 首次性生活年龄、丈夫婚外性行为、生产次数、流产史、性伴侣数、生殖系统感染。logistic回归分析结果表明：首次性生活年龄（≤20）、丈夫婚外性行为、生产次数（>1）、流产史、性伴侣数（>1）、生殖系统感染是HPV感染的危险因素。结论 深圳妇女HPV感染率较高,最常见感染型别为 HPV 52,其次是 HPV 16、HPV 53、HPV 51和HPV 58。感染高峰年龄为30~<40岁和45~<60岁。初次性生活年龄、性伴侣数及妊娠次数、流产、丈夫婚外性行为和生殖系统感染是影响HPV感染的危险因素。

Risk factors of female HPV infection in Shenzhen

Objective To investigate the risk factors affecting human papillomavirus (HPV) infection in Shenzhen, and to provide evidence for the prevention and treatment of HPV infection and cervical cancer. Methods Women's disease screening was conducted in Shenzhen for 2 694 women from January 2011 to December 2015. Questionnaires, liquid-based thin-layer cytology (TCT) and cervical HPV DNA testing, colposcopy, tissue biopsy and pathological examination were performed to analyze HPV infection in different age groups. Multivariate unconditional logistic regression model was used to analyze the risk factors of HPV infection. Results The infection rate of HPV was 17.8% (480 cases), and the high-risk and low-risk HPV infection rates were 16.0% and 1.8%, respectively. 432 cases of high-risk HPV infection were mainly type 52, type 16, type 53, type 51 and type 58 with infection rates of 3.6%, 1.9%, 1.5%, 1.4%, and 1.2%, respectively. In 48 cases, the main pathogenic subtypes were HPV81 (0.8%), HPV6 (0.3%) and HPV11 (0.2%). After univariate analysis, the variables with significant statistical significance were as follows: first sexual life age, husband's extramarital sex, production frequency, abortion history, sexual partner number, reproductive system infection. Logistic regression analysis showed that the first sexual life age (≤20), husband's extramarital sex, production times (>1), abortion history, sexual partners (>1), reproductive system infection were the risk factors for HPV infection. Conclusions henzhen women have a higher HPV infection rate, mainly high-risk HPV infection. The most common infection type is HPV52, followed by HPV16, HPV53, HPV51 and HPV58. The peak ages of infection are 30 to 40 years old and 45 to 60 years old. The age of first sexual life, the number of sexual partners and the number of pregnancies, miscarriage, husband's extramarital sexual behavior and reproductive system infection are the risk factors for HPV infection.