The host range of herpes simplex virus: Interferon,viral DNA,and antigen synthesis in abortive infection of dog kidney cells |
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| Affiliation: | 1. USDA, ARS, Avian Disease and Oncology Laboratory, East Lansing, MI, United States;2. Department of Animal Sciences, Bond Life Sciences Center, University of Missouri, Columbia, MO, United States;3. Department of Animal Science, University of California, Davis, CA, United States |
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| Abstract: | Herpes simplex virus strain MP (HSV-MP) and pseudorabies virus (PSV) multiply in HEp-2 cells. In dog kidney cells PSV multiplies, whereas HSV-MP fails to multiply or to produce plaques. HSV-MP interferes with the multiplication of PSV in HEp-2 cells and in dog kidney cells. Studies of dog kidney cells exposed to HSV-MP revealed that these cells (1) produce viral antigen, interferon, and small amounts of DNA characteristic of HSV-DNA, (2) do not form particles with physical characteristics of HSV-MP, and (3) show signs of infection and fail to multiply. The significance of the data is discussed. |
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