99Tc- MDP对骨重建的影响

双膦酸盐主要用于治疗以破骨细胞活性增加为病理特征的代谢性骨病,包括Paget's骨病(派杰氏病),肿瘤骨转移,恶性肿瘤引起的高钙血症和骨质疏松。从P-O-P结构的焦磷酸盐到P-C-P结构的第三代双膦酸盐,其抗骨吸收的作用随碳链接侧链的延长而增强。锝99Tc]亚甲基二膦酸盐(99Tc-MDP)是双膦酸盐的一种,其主要成分是锝99Tc]经氯化亚锡还原后与亚甲基二膦酸盐形成的螯合物,具有稳定的P-C-P键,被骨生成区和带有炎症的骨与软骨组织摄取,不仅有效降低血中免疫调节因子、抑制病理复合物产生;而且多项国内外研究发现,99Tc-MDP免疫调节同时具有抑制破骨细胞活性及修复破骨的作用,引起骨质疏松研究者的关注。本文综述了99Tc-MDP对骨重建影响的研究进展。

The effect of 99Tc-MDP on bone remodeling

Bisphosphonates are mainly used in the treatment of metabolic bone diseases, which is characterized by the pathological features of increased osteoclast activity, including Paget''s bone diseases (Paget''s disease), bone metastases, tumor-induced hypercalcemia, and osteoporosis. From the P-O-P structure in pyrophosphate to the P-C-P structure in the 3rd generation bisphosphonate, the anti-resorption effect enhances with the extension of the carbon linked side chains. Technetium 99Tc] methylenediphosphonate (99Tc-MDP), a kind of bisphosphonate, mainly constitutes the chelate formed by the reduced technetium 99Tc], after reacting with the stannous chloride, and the methylene bisphosphonate. It has a stable P-C-P bond, which can be absorbed by bone formation area and bone or cartilage tissues with inflammation. It can not only effectively reduce the blood immunomodulatory factors and inhibit pathological complexes producing, but also inhibit osteoclast activity and repair the broken bone in various national and international studies, which has caused much attention by osteoporosis researchers. This paper reviews the research progress of the effect of 99Tc-MDP on bone remodeling.