运动训练对糖尿病大鼠尾神经传导速度的影响 |
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引用本文: | 李红卫,江钟立,吴亚文,陈 玲.运动训练对糖尿病大鼠尾神经传导速度的影响[J].中国康复医学杂志,2009,24(5):412-415. |
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作者姓名: | 李红卫 江钟立 吴亚文 陈 玲 |
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作者单位: | 1. 南京医科大学第一附属医院康复医学科,210029 2. 南京医科大学生理学系 |
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摘 要: | 目的:探讨运动训练对糖尿病大鼠尾神经传导速度(CNCV)的影响。方法:链脲霉素(STZ,55mg/kg)诱导的21只糖尿病大鼠随机平均分配到糖尿病运动8周组(A)、糖尿病运动4周组(B)和糖尿病对照组(C),实验结束时17只糖尿病大鼠存活,其中A组6只、B组6只和C组5只;12只正常血糖大鼠随机分为正常运动8周组(D,n=6)和正常对照组(E,n=6)。运动组大鼠游泳60min/d,5d/周。实验过程中分别于基线、第4周、第8周时测定大鼠血糖、体重和CNCV。结果:糖尿病大鼠基线时血糖显著高于正常血糖大鼠
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关 键 词: | 运动训练 糖尿病神经病变 尾神经传导速度 |
收稿时间: | 2009/1/15 0:00:00 |
The effect of exercises training on caudal nerve conduction velocity in diabetic rats |
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Institution: | Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 |
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Abstract: | Objective: To explore the effect of exercises on caudal nerve conduction velocity(CNCV) in streptozotocin-induced diabetic rats. Method: Twenty-one diabetic rats induced by streptozotocin(STZ, 55mg/kg) were randomly divided into diabetic group A with exercises for 8 weeks, diabetic group B with exercises for 4 weeks and diabetic control group C without exercises. Seventeen diabetic rats survived at the end of experiment, which were distributed respectively in group A(n=6), group B(n=6) and group C(n=5). Twelve SD rats with euglycemia were randomly divided into normal exercises 8 weeks group D(n=6) and normal control group E(n=6). The exercises rats were forced to swim 60min/d with 5d/week. Body weights, blood glucose and CNCV in all rats were evaluated at the points of baseline, the 4th week and 8th week. Result: Blood glucose in diabetic rats were higher than that in rats with euglycemia (P<0.05). Blood glucose in group A decreased significantly after 8 weeks exercises in comparison with baseline (P<0.05). The CNCV were significantly lower in all diabetic groups than that in groups with euglycemia and were significantly higher in group A than those in groups B and C at the 4th week. The CNCV in groups A and B increased significantly beyond baseline(P<0.05) and to normal level as the groups with euglycemia at the 8th week. The CNCV in group C at the 8th week decreased significantly in comparison with baseline (P<0.05). The CNCV in groups D and E at the 8th week increased significantly in comparison with baseline. Conclusion: Exercises training may prevent and treat the diabetic neuropathy. |
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Keywords: | exercises training diabetic neuropathy caudal nerve conduction velocity |
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