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miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases |
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| Authors: | Qinhong Xu Pei Li Xin Chen Liang Zong Zhengdong Jiang Ligang Nan Jianjun Lei Wanxing Duan Dong Zhang Xuqi Li Huanchen Sha Zheng Wu Qingyong Ma Zheng Wang |
| Affiliation: | 1. Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi''an Jiaotong University, Xi''an, Shaanxi, China;2. Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi''an, Shaanxi, China;3. Department of General Surgery, First Affiliated Hospital Medical College of Xi''an Jiaotong University, Xi''an, Shaanxi, China |
| Abstract: | MicroRNAs are involved in the initiation and progression of pancreatic cancer. In this study, we showed that miR-221/222 is overexpressed in pancreatic cancer. MiR-221/222 overexpression significantly promoted pancreatic cancer cell proliferation and invasion while inhibiting apoptosis. The expression of the matrix metalloproteinases (MMPs) MMP-2 and MMP-9 was increased in miR-221/222 mimic-transfected pancreatic cancer cells. Validation experiments identified TIMP-2 as a direct target of miR-221/222. These data indicate that overexpressed miR-221/222 may play an oncogenic role in pancreatic cancer by inducing the expression of MMP-2 and MMP-9, thus leading to cancer cell invasion. |
| Keywords: | miR-221/222 pancreatic cancer Matrix metalloproteinases |