Tracheobronchial lesions in eosinophilic pneumonia |
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| Affiliation: | 1. Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Rome, Italy;2. Department of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy;3. Department of Medicine, Surgery and Health Sciences, University of Trieste and Department of Mental Health, Azienda Sanitaria Universitaria Giuliano Isontina – ASUGI, Trieste, Italy;4. Department of Medicine and Surgery, University of Milan Bicocca, Milan, Italy;5. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy;6. Center for Behavioral Sciences and Mental Health, National Institute of Health, Rome, Italy;7. Department of Biomedical and Clinical Sciences Luigi Sacco and Aldo Ravelli Center for Neurotechnology and Brain Therapeutic, University of Milan, Milano, Italy;8. Department of Psychiatry, University of Perugia, Perugia, Italy;9. Institute of Psychiatry, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, Italy;10. Department of Neurosciences, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy;11. Clinical Psychiatry Unit, Department of Clinical Neurosciences, Università Politecnica delle Marche, Ancona, Italy;12. Department of Psychiatry, University of Campania “L. Vanvitelli”, Naples, Italy |
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| Abstract: | BackgroundEosinophilic pneumonia (EP) is characterized by eosinophil infiltration in the lung parenchyma. However, tracheobronchial lesions associated with the disease have been poorly described. To clarify the frequency and characteristics of cases with tracheobronchial lesions in EP, we performed a retrospective review of EP patients.MethodsWe included 36 EP cases seen from January 2004 to December 2007 at the Kinki-Chuo Chest Medical Center. The incidence of tracheobronchial nodules and associated clinical features were analyzed.ResultsOf these 36 patients, 29 had chronic eosinophilic pneumonia (CEP); 1, acute EP; 3, drug-induced EP; 2, allergic bronchopulmonary aspergillosis; and 1, parasite-related EP. Only 2 of the 29 CEP cases had tracheobronchial lesions. For both of these cases, bronchoscopy revealed multiple whitish nodules on the tracheobronchial mucosa. The associated histopathological findings revealed squamous metaplasia and eosinophil infiltration in the subepithelial region. In both cases, the nodules disappeared after steroid therapy. The prevalence of tracheobronchial lesions was 6.9% in CEP patients and 5.6% in EP patients overall. EP patients were divided into 3 groups: CEP with nodules (n=2), CEP without nodules (n=27), and other EP (n=7). We found that the CEP with nodules group showed a relatively higher incidence of respiratory symptoms, higher white blood cell (WBC) count, and higher levels of peripheral and bronchoalveolar eosinophilia than the other groups.ConclusionsTracheobronchial nodules represent rare observations within the EP population, which are likely to reflect a severe disease condition. |
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| Keywords: | Tracheobronchial lesions Eosinophilic pneumonia Chronic eosinophilic pneumonia Bronchoscopy |
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