Structure-Based Design of GNE-495, a Potent and Selective
MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis |
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| Authors: | Chudi O. Ndubaku,Terry
D. Crawford,Huifen Chen,Jason
W. Boggs,Joy Drobnick,Seth F. Harris,Rajiv Jesudason,Erin McNamara,Jim Nonomiya,Amy Sambrone,Stephen Schmidt,Tanya Smyczek,Philip Vitorino,Lan Wang,Ping Wu,Stacey Yeung,Jinhua Chen,Kevin Chen,Charles
Z. Ding,Tao Wang,Zijin Xu,Stephen E. Gould,Lesley J. Murray,Weilan Ye |
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| Affiliation: | †Genentech,Inc., 1 DNA Way, South San Francisco, California 94080, United States;‡WuxiApptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People’sRepublic of China |
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| Abstract: | ![]()
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| Keywords: | Angiogenesis MAP4K4 naphthyridine GNE-495 P loop |
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